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FES antibody (Feline Sarcoma Oncogene)

Details for Product anti-FES Antibody No. ABIN1105571, Supplier: Log in to see
Antigen
  • FES
  • c-fps
  • FPS
  • AI586313
  • BB137047
  • c-fes
  • RGD1564385
Reactivity
Human
74
23
15
1
1
1
Host
Mouse
45
28
2
Clonality (Clone)
Monoclonal ()
Conjugate
This FES antibody is un-conjugated
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
64
38
24
4
2
2
2
2
1
Supplier
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Clone 2E3G3
Isotype IgG1
Specificity Recognizes FES (Feline Sarcoma Oncogene).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name C-Fes (FES Antibody Abstract)
Background FES (Feline Sarcoma Oncogene) and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. FES and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains. FES was originally identified as an oncogene from avian and feline retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. FES has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Mutations may activate the FES kinase and thereby contribute to cancer. However, recent data strongly suggests that the c-FES protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.Synonyms: FES, FPS, Proto-oncogene c-Fps, Proto-oncogene tyrosine-protein kinase Fes/Fps
Gene ID 2242
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Western Blotting (WB) image for anti-FES antibody (Feline Sarcoma Oncogene) (ABIN1105571) anti-Feline Sarcoma Oncogene (FES) antibody
Immunohistochemistry (IHC) image for anti-FES antibody (Feline Sarcoma Oncogene) (ABIN1105571) anti-Feline Sarcoma Oncogene (FES) antibody (Image 2)
Background publications Noginov, Novak, Grigsby et al.: "Optimization of the transport mean free path and the absorption length in random lasers with non-resonant feedback." in: Optics express, Vol. 13, Issue 22, pp. 8829-36, 2009 (PubMed).

Delfino, Stevenson, Smithgall: "A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer." in: The Journal of biological chemistry, Vol. 281, Issue 13, pp. 8829-35, 2006 (PubMed).

Durfee, Rivard: "Design and simulation of a pneumatic, stored-energy, hybrid orthosis for gait restoration." in: Journal of biomechanical engineering, Vol. 127, Issue 6, pp. 1014-9, 2006 (PubMed).