DREAM antibody (N-Term)

Catalog No. ABIN1105647

Product Details anti-DREAM Antibody

Target: DREAM (KCNIP3) (Kv Channel Interacting Protein 3, Calsenilin (KCNIP3))

Binding Specificity: N-Term

Reactivity: Human, Dog, Cow

Host: Goat

Clonality: Polyclonal

Conjugate: This DREAM antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: SLLGDLGHTP LS-C

Specificity: This antibody is expected to recognize Isoform 1 of KCNIP3 (NP_038462.1) only.

Cross-Reactivity (Details): Species reactivity (expected):Canine (Dog), Bovine.
Species reactivity (tested):Human.

Purification: Purification: Affinity Chromatography

Immunogen: Synthetic peptide with sequence from the N-terminus of Human KCNIP3 (NP_038462.1). Genename: KCNIP3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for DREAM

Target: DREAM (KCNIP3) (Kv Channel Interacting Protein 3, Calsenilin (KCNIP3))

Alternative Name: Calsenilin (KCNIP3 Products)

Synonyms: CSEN antibody, DREAM antibody, KCHIP3 antibody, 4933407H12Rik antibody, AI413860 antibody, Csen antibody, KChIP3 antibody, R74849 antibody, Dream antibody, rKChIP3 antibody, csen antibody, im:7145308 antibody, kcnip3 antibody, zgc:73306 antibody, KCNIP3 antibody, potassium voltage-gated channel interacting protein 3 antibody, Kv channel-interacting protein 4 antibody, calsenilin antibody, Kv channel interacting protein 3, calsenilin antibody, Kv channel interacting protein 3b, calsenilin antibody, KCNIP3 antibody, LOC5568664 antibody, CpipJ_CPIJ002549 antibody, Tsp_05009 antibody, Kcnip3 antibody, kcnip3b antibody, kcnip3 antibody

Background: KChIP3 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein is also shown to function as a calcium-regulated transcriptional repressor, and to interact with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease. Due to utilization of an alternate in-frame translation start codon, the gene for this protein encodes two isoforms with different sizes.Synonyms: A-type potassium channel modulatory protein 3, CSEN, DRE-antagonist modulator, DREAM, KCHIP3, KCNIP3, Kv channel-interacting protein 3

Molecular Weight: 29.2 kDa according to NP_038462.1.

Gene ID: 30818

NCBI Accession: NP_001030086