Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody

Details for Product No. ABIN1105691
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Antigen
Synonyms Jup, LOC100217813, CTNNB1, CTNNB, Bfc, Catnb, Mesc, ctnnb, id:ibd2058, wu:fb73e10, wu:fi81c06, wu:fk25h01, ctnnb1, CHBCAT, MRD19, armadillo, beta-catenin
Reactivity
Human
(409), (107), (88), (15), (12), (12), (5), (4), (4), (4), (3), (2), (1), (1), (1)
Host
Mouse
(292), (140), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(9), (6), (6), (3), (3), (3), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(398), (141), (101), (90), (89), (87), (50), (33), (31), (24), (12), (7), (3), (3), (2), (1)
Pubmed 3 references available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN1105691
390.50 $
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Clone 4D5
Isotype IgG1
Specificity This antibody reacts to CTNNB1.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name Catenin beta-1
Background The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. The distinct peripheral cytosolic proteins, alpha, beta and gamma catenin (102, 94 and 86 kDa) are found in many tissues and bind to the conserved cytoplasmic tail domain of the cell adhesion cadherins. Catenins link E cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt1 proto oncogene. The central core region of beta catenin is involved in mediation of cadherin catenin complex interaction with EGFR. Beta-Catenin-mediated signalling is involved at several stages of vertebrate neural development.Synonyms: Beta-catenin, CTNNB, CTNNB1
Molecular Weight 85 kDa
Gene ID 1499
Research Area Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody (2) anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody (Image 2)
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody (3) anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody (Image 3)
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody (4) anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody (Image 4)
Background publications Rubinfeld, Souza, Albert et al.: "The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin." in: The Journal of biological chemistry, Vol. 270, Issue 10, pp. 5549-55, 1995 (PubMed).

Guo, Liu, Yang et al.: "Relation among p130Cas, E-cadherin and beta-catenin expression, clinicopathologic significance and prognosis in human hepatocellular carcinoma." in: Hepatobiliary & pancreatic diseases international : HBPD INT, Vol. 7, Issue 5, pp. 490-6, 2008 (PubMed).

Bougatef, Ouerhani, Moussa et al.: "Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer." in: Cancer genetics and cytogenetics, Vol. 187, Issue 1, pp. 12-8, 2008 (PubMed).

Validation Images
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