CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence)

Details for Product anti-CBL Antibody No. ABIN1105707, Supplier: Log in to see
Antigen
  • 4732447J05Rik
  • Cbl-2
  • c-Cbl
  • cbl
  • C-CBL
  • CBL2
  • FRA11B
  • NSLL
  • RNF55
  • c-cbl-like
  • RGD1561386
  • Casitas B-lineage lymphoma
  • Cbl proto-oncogene, E3 ubiquitin protein ligase
  • Cbl
  • CBL
Alternatives
anti-Human CBL antibody for Western Blotting
Reactivity
Human, Mouse (Murine), Rat (Rattus)
276
171
161
7
6
4
4
3
3
1
1
1
Host
Mouse
221
44
16
1
Clonality (Clone)
Monoclonal ()
Conjugate
This CBL antibody is un-conjugated
7
7
7
7
6
5
5
5
5
5
5
5
5
5
4
2
2
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
196
75
74
65
61
49
20
16
11
6
5
3
3
2
1
1
1
1
Options
Supplier
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Supplier Product No.
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Clone 3B12
Isotype IgG1
Specificity This antibody reacts to C-CBL.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse and Rat.
Purification Ascites
Alternative Name CBL / RNF55 (CBL Antibody Abstract)
Background The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.Synonyms: CBL2, Casitas B-lineage lymphoma proto-oncogene, E3 ubiquitin-protein ligase CBL, Proto-oncogene c-CBL, RING finger protein 55, Signal transduction protein CBL, c-CBL
Molecular Weight 120 kDa
Gene ID 867
Pathways TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway, EGFR Downregulation, VEGFR1 Specific Signals
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Immunohistochemistry (IHC) image for anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody
Immunohistochemistry (IHC) image for anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 2)
Flow Cytometry (FACS) image for anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 3)
Immunofluorescence (IF) image for anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 4)
Western Blotting (WB) image for anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 5)
Western Blotting (WB) image for anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 6)
ELISA image for anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 7)
Background publications Sproul, Xu, Wilhelm, Gire, Greene: "Cbl negatively regulates JNK activation and cell death." in: Cell research, Vol. 19, Issue 8, pp. 950-61, 2009 (PubMed).

Loh, Sakai, Flotho, Kang, Fliegauf, Archambeault, Mullighan, Chen, Bergstraesser, Bueso-Ramos, Emanuel, Hasle, Issa, van den Heuvel-Eibrink, Locatelli, Stary, Trebo, Wlodarski, Zecca, Shannon et al.: "Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. ..." in: Blood, Vol. 114, Issue 9, pp. 1859-63, 2009 (PubMed).

Sanada, Suzuki, Shih, Otsu, Kato, Yamazaki, Tamura, Honda, Sakata-Yanagimoto, Kumano, Oda, Yamagata, Takita, Gotoh, Nakazaki, Kawamata, Onodera, Nobuyoshi, Hayashi, Harada, Kurokawa, Chiba, Mori et al.: "Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. ..." in: Nature, Vol. 460, Issue 7257, pp. 904-8, 2009 (PubMed).

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