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CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence)

Details for Product anti-CBL Antibody No. ABIN1105707, Supplier: Log in to see
Antigen
  • 4732447J05Rik
  • Cbl-2
  • c-Cbl
  • cbl
  • C-CBL
  • CBL2
  • FRA11B
  • NSLL
  • RNF55
  • c-cbl-like
  • RGD1561386
Alternatives
anti-Human CBL antibody for Western Blotting
Reactivity
Human, Mouse (Murine), Rat (Rattus)
246
132
126
6
4
4
4
1
1
1
Host
Mouse
200
34
16
1
Clonality (Clone)
Monoclonal ()
Conjugate
This CBL antibody is un-conjugated
7
7
7
7
6
6
5
5
5
5
5
5
4
2
2
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
164
68
66
56
50
29
18
13
5
5
3
3
3
1
1
1
1
1
Supplier
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Clone 3B12
Isotype IgG1
Specificity This antibody reacts to C-CBL.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse and Rat.
Purification Ascites
Alternative Name CBL / RNF55 (CBL Antibody Abstract)
Background The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.Synonyms: CBL2, Casitas B-lineage lymphoma proto-oncogene, E3 ubiquitin-protein ligase CBL, Proto-oncogene c-CBL, RING finger protein 55, Signal transduction protein CBL, c-CBL
Molecular Weight 120 kDa
Gene ID 867
Pathways TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Immunohistochemistry (IHC) image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody
Immunohistochemistry (IHC) image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 2)
Flow Cytometry (FACS) image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 3)
Immunofluorescence (IF) image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 4)
Western Blotting (WB) image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 5)
Western Blotting (WB) image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 6)
ELISA image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 7)
Background publications Sanada, Suzuki, Shih et al.: "Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. ..." in: Nature, Vol. 460, Issue 7257, pp. 904-8, 2009 (PubMed).

Loh, Sakai, Flotho et al.: "Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. ..." in: Blood, Vol. 114, Issue 9, pp. 1859-63, 2009 (PubMed).

Sproul, Xu, Wilhelm et al.: "Cbl negatively regulates JNK activation and cell death." in: Cell research, Vol. 19, Issue 8, pp. 950-61, 2009 (PubMed).