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CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence)

Details for Product anti-CBL Antibody No. ABIN1105707, Supplier: Login to see New
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Antigen
Synonyms 4732447J05Rik, Cbl-2, c-Cbl, cbl, C-CBL, CBL2, FRA11B, NSLL, RNF55, c-cbl-like, RGD1561386
Alternatives
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
(238), (132), (126), (6), (4), (4), (4), (1), (1), (1)
Host
Mouse
(199), (32), (11), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
This CBL antibody is un-conjugated
(7), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (2)
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(160), (67), (60), (56), (53), (33), (22), (18), (9), (5), (3), (3), (3), (1), (1), (1), (1), (1)
Pubmed 3 references available
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Quantity 0.1 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Clone 3B12
Isotype IgG1
Specificity This antibody reacts to C-CBL.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse and Rat.
Purification Ascites
Alternative Name CBL / RNF55 (CBL Antibody Abstract)
Background The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.Synonyms: CBL2, Casitas B-lineage lymphoma proto-oncogene, E3 ubiquitin-protein ligase CBL, Proto-oncogene c-CBL, RING finger protein 55, Signal transduction protein CBL, c-CBL
Molecular Weight 120 kDa
Gene ID 867
Pathways TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Immunohistochemistry (IHC) image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody
Immunohistochemistry (IHC) image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 2)
Flow Cytometry (FACS) image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 3)
Immunofluorescence (IF) image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 4)
Western Blotting (WB) image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 5)
Western Blotting (WB) image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 6)
ELISA image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (ABIN1105707) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody (Image 7)
Background publications Sanada, Suzuki, Shih et al.: "Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. ..." in: Nature, Vol. 460, Issue 7257, pp. 904-8, 2009 (PubMed).

Loh, Sakai, Flotho et al.: "Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. ..." in: Blood, Vol. 114, Issue 9, pp. 1859-63, 2009 (PubMed).

Sproul, Xu, Wilhelm et al.: "Cbl negatively regulates JNK activation and cell death." in: Cell research, Vol. 19, Issue 8, pp. 950-61, 2009 (PubMed).

Catalog No. ABIN1105707
$423.50
Plus shipping costs $45.00

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