ITGAE antibody (Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide)) (PE)

Details for Product anti-ITGAE Antibody No. ABIN1105731, Supplier: Log in to see
Antigen
  • A530055J10
  • CD103
  • aM290
  • alpha-E1
  • alpha-M290
  • HUMINAE
  • integrin alpha E, epithelial-associated
  • integrin, alpha E
  • integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
  • Itgae
  • ITGAE
Reactivity
Human, Primate
217
108
23
23
11
4
2
2
Host
Mouse
190
63
46
19
9
7
1
Clonality (Clone)
Monoclonal ()
Conjugate
This ITGAE antibody is conjugated to PE
45
42
23
14
10
10
6
5
5
5
5
5
5
5
5
4
4
3
3
3
2
2
2
2
1
1
1
Application
Flow Cytometry (FACS)
250
126
99
92
87
35
19
11
8
7
5
4
4
4
2
2
2
2
2
1
1
Options
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Immunogen HTLV-1 induced human T cell line MAPS16
Clone Ber-ACT8
Isotype IgG1
Specificity The mouse monoclonal antibody Ber-ACT8 recognizes CD103 (alpha E integrin), a type I transmembrane glycoprotein primarily found on intestinal intraepithelial lymphocytes.
Cross-Reactivity (Details) Species reactivity (tested):Human, Non-Human Primates
Alternative Name CD103 (ITGAE Antibody Abstract)
Background CD103 / Integrin alphaE is an integrin subunit that is expressed on intraepithelial lymphocytes, epithelial dendritic cells, lamina propria-derived dendritic cells, a subpopulation of lamina propria T cells, a small subset of peripheral lymphocytes, namely T reg cells, and on activated and TGF-beta stimulated lymphocytes. CD103 is in mature form cleaved into two disulfide-linked chains (C-terminal 150 kDa chain and N-terminal 25 kDa chain). It heterodimerizes with integrin beta7 subunit to form alphaE/beta7 integrin (mucosal lymphocyte 1 antigen), which through binding E-cadherin mediates homing of lymphocytes to the intestinal epithelium, and, in addition to the role in adhesion, may serve as an accessory molecule for intraepithelial lymphocyte activation.Synonyms: HML-1 antigen, ITGAE, Integrin alpha-E, Integrin alpha-IEL, Mucosal lymphocyte 1 antigen
Gene ID 3682
NCBI Accession NP_002199
UniProt P38570
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS, 15 mM sodium azide, 0.2 % (w/v) high-grade protease free Bovine Serum Albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE! This product is photosensitive and should be protected from light.
Storage 4 °C
Background publications Zhang, Bertucci, Ramsey-Goldman, Burt, Datta et al.: "Regulatory T cell (Treg) subsets return in patients with refractory lupus following stem cell transplantation, and TGF-beta-producing CD8+ Treg cells are associated with immunological remission of ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 10, pp. 6346-58, 2009 (PubMed).

Cardoso, Garlet, Moreira, Júnior, Rossi, Silva: "Characterization of CD4+CD25+ natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis." in: Journal of leukocyte biology, Vol. 84, Issue 1, pp. 311-8, 2008 (PubMed).

Kost, Holden, Mann: "Marginal zone B-cell lymphoma: a retrospective immunophenotypic analysis." in: Cytometry. Part B, Clinical cytometry, Vol. 74, Issue 5, pp. 282-6, 2008 (PubMed).

Jaensson, Uronen-Hansson, Pabst, Eksteen, Tian, Coombes, Berg, Davidsson, Powrie, Johansson-Lindbom, Agace: "Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans." in: The Journal of experimental medicine, Vol. 205, Issue 9, pp. 2139-49, 2008 (PubMed).

Sigmundsdottir, Johnston, Gudjonsson, Bjarnason, Valdimarsson: "Methotrexate markedly reduces the expression of vascular E-selectin, cutaneous lymphocyte-associated antigen and the numbers of mononuclear leucocytes in psoriatic skin." in: Experimental dermatology, Vol. 13, Issue 7, pp. 426-34, 2004 (PubMed).

León, Roy: "Isolation of human small bowel intraepithelial lymphocytes by annexin V-coated magnetic beads." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 84, Issue 6, pp. 804-9, 2004 (PubMed).

Poles, Barsoum, Yu, Yu, Sun, Daly, He, Mehandru, Talal, Markowitz, Hurley, Ho, Zhang: "Human immunodeficiency virus type 1 induces persistent changes in mucosal and blood gammadelta T cells despite suppressive therapy." in: Journal of virology, Vol. 77, Issue 19, pp. 10456-67, 2003 (PubMed).

Brandes, Willimann, Lang, Nam, Jin, Brenner, Morita, Moser: "Flexible migration program regulates gamma delta T-cell involvement in humoral immunity." in: Blood, Vol. 102, Issue 10, pp. 3693-701, 2003 (PubMed).

French, Cresswell, Wong, Seymour, Charnley, Kirby: "T cell adhesion and cytolysis of pancreatic cancer cells: a role for E-cadherin in immunotherapy?" in: British journal of cancer, Vol. 87, Issue 9, pp. 1034-41, 2002 (PubMed).