PVRL2 antibody (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B)) (Extracellular Domain)

Details for Product anti-PVRL2 Antibody No. ABIN1105751, Supplier: Log in to see
Antigen
  • prr2
  • AI325026
  • AI987993
  • Cd112
  • MPH
  • Pvr
  • Pvs
  • nectin-2
  • CD112
  • HVEB
  • PRR2
  • PVRR2
  • poliovirus receptor-related 2 (herpesvirus entry mediator B)
  • poliovirus receptor-related 2
  • Pvrl2
  • PVRL2
Alternatives
anti-Mouse (Murine) PVRL2 antibody for ELISA
Epitope
Extracellular Domain
15
12
11
8
7
6
5
4
3
3
3
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
102
57
21
2
1
Host
Rat
62
40
33
1
Clonality (Clone)
Monoclonal ()
Conjugate
This PVRL2 antibody is un-conjugated
11
7
3
3
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
66
46
33
29
28
16
13
11
5
3
3
2
2
1
1
1
1
Options
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Immunogen Extracellular domain of mouse nectin-2
Clone 502-57
Isotype IgG2a
Specificity This antibody detects Nectin-2 at extracellular domain.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse.
Purification Protein G
Alternative Name CD112 / Nectin 2 (PVRL2 Antibody Abstract)
Background Nectin (originally isolated as poliovirus receptor-related protein (PRR)) is a cell-cell adhesion molecule of the immunoglobulin supergene family. Nectin is colocalized with afadin at cadherin-based cell-cell adherence junctions in various tissues and cell lines. The nectin family consist of nectin-1, nectin-2 and nectin-3. Nectin-2 also known as PRR2 or CD112 is a plasma membrane adhesion molecule localized at adherens junctions which is widely expressed in various cell lines including neuronal, endothelial, epithelial and hematopoietic cells. Next to its role in adherens junctions it functions as alphaherpus virus receptor and acts also as intercellular adhesion molecule and pseudorabies virus receptor. Disruption of mouse nectin-2 leads to infertility of male mice.Synonyms: HVEB, Herpes virus entry mediator B, Nectin-2, PRR2, PVRL2, Poliovirus receptor-related protein 2
Gene ID 19294
NCBI Accession NP_001153196
UniProt P32507
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.02 % Sodium Azide, 0.1 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2 - 8 °C.
Background publications Kawabe, Nakanishi, Asada, Fukuhara, Morimoto, Takeuchi, Takai: "Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells." in: The Journal of biological chemistry, Vol. 276, Issue 51, pp. 48350-5, 2001 (PubMed).

Sakisaka, Nakanishi, Takahashi, Mandai, Miyahara, Satoh, Takaishi, Takai: "Different behavior of l-afadin and neurabin-II during the formation and destruction of cell-cell adherens junction." in: Oncogene, Vol. 18, Issue 8, pp. 1609-17, 1999 (PubMed).

Takahashi, Nakanishi, Miyahara, Mandai, Satoh, Satoh, Nishioka, Aoki, Nomoto, Mizoguchi, Takai: "Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein." in: The Journal of cell biology, Vol. 145, Issue 3, pp. 539-49, 1999 (PubMed).