KIT antibody (Mast/stem Cell Growth Factor Receptor) (C-Term)

Details for Product anti-KIT Antibody No. ABIN1105763, Supplier: Log in to see
Antigen
  • C-Kit
  • CD117
  • PBT
  • SCFR
  • Bs
  • Fdc
  • Gsfsco1
  • Gsfsco5
  • Gsfsow3
  • SCO1
  • SCO5
  • SOW3
  • Ssm
  • Tr-kit
  • W
  • c-KIT
  • c-kit
  • MGF
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • kit oncogene
  • KIT
  • Kit
Alternatives
anti-Human KIT antibody for Immunofluorescence
Epitope
C-Term
98
83
67
64
47
38
35
34
33
33
27
20
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Reactivity
Human
1382
595
163
48
42
37
29
19
15
6
6
5
5
4
3
2
1
1
Host
Rabbit
1090
353
277
16
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
This KIT antibody is un-conjugated
150
132
128
100
86
74
25
21
15
13
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Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
705
655
496
360
275
181
122
105
85
81
39
14
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12
8
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3
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Options
Supplier
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Supplier Product No.
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Clone YR145
Isotype IgG
Specificity This antibody reacts to CD117.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Supernatant
Alternative Name CD117 / C-Kit (KIT Antibody Abstract)
Background CD117, c-kit is a tyrosine kinase receptor found on interstitial cells of Cajal, germ cells, bone marrow stem cells, melanocytes, breast epithelium and mast cells. This receptor is found on a wide variety of tumor cells (follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, breast, malignant melanoma, endodermal sinus tumor, and small cell carcinoma) but has been particularly useful in differentiating gastrointestinal stromal tumors from Kaposi's sarcoma, and tumors of smooth muscle origin.Synonyms: KIT, Mast/stem cell growth factor receptor, Proto-Oncogene Tyrosine-Protein Kinase, SCFR
Gene ID 3815
NCBI Accession NP_000213
UniProt P10721
Research Area CD Antigens, Surface Receptors of Immune Cells, Growth Factors, Receptors, Proliferation Markers
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer PBS, pH 7.4, 0,09 % sodium azide, 0,9 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications de Silva, Reid: "Gastrointestinal stromal tumors (GIST): C-kit mutations, CD117 expression, differential diagnosis and targeted cancer therapy with Imatinib." in: Pathology oncology research : POR, Vol. 9, Issue 1, pp. 13-9, 2003 (PubMed).

Naeem, Dahiya, Clark, Creech, Alkan: "Analysis of c-kit protein expression in small-cell lung carcinoma and its implication for prognosis." in: Human pathology, Vol. 33, Issue 12, pp. 1182-7, 2003 (PubMed).

Chen, Yanuck, Abbondanzo, Chu, Aguilera: "c-Kit (CD117) reactivity in extramedullary myeloid tumor/granulocytic sarcoma." in: Archives of pathology & laboratory medicine, Vol. 125, Issue 11, pp. 1448-52, 2001 (PubMed).

Graadt van Roggen, van Velthuysen, Hogendoorn: "The histopathological differential diagnosis of gastrointestinal stromal tumours." in: Journal of clinical pathology, Vol. 54, Issue 2, pp. 96-102, 2001 (PubMed).

Elmore, Domson, Moore, Kornstein, Burks: "Expression of c-kit (CD117) in benign and malignant human endometrial epithelium." in: Archives of pathology & laboratory medicine, Vol. 125, Issue 1, pp. 146-51, 2001 (PubMed).

Miettinen, Sarlomo-Rikala, Sobin, Lasota: "Esophageal stromal tumors: a clinicopathologic, immunohistochemical, and molecular genetic study of 17 cases and comparison with esophageal leiomyomas and leiomyosarcomas." in: The American journal of surgical pathology, Vol. 24, Issue 2, pp. 211-22, 2000 (PubMed).

Sircar, Hewlett, Huizinga, Chorneyko, Berezin, Riddell: "Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors." in: The American journal of surgical pathology, Vol. 23, Issue 4, pp. 377-89, 1999 (PubMed).

Miettinen, Monihan, Sarlomo-Rikala, Kovatich, Carr, Emory, Sobin: "Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases." in: The American journal of surgical pathology, Vol. 23, Issue 9, pp. 1109-18, 1999 (PubMed).

Kirschstein: "Editorial: cyclamates." in: Human pathology, Vol. 5, Issue 4, pp. 498-9, 1974 (PubMed).

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