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KIT antibody (Mast/stem Cell Growth Factor Receptor) (C-Term)

Details for Product anti-KIT Antibody No. ABIN1105763, Supplier: Log in to see
Antigen
  • Bs
  • C-Kit
  • c-kit
  • c-KIT
  • CD117
  • Fdc
  • Gsfsco1
  • Gsfsco5
  • Gsfsow3
  • MGF
  • PBT
  • SCFR
  • SCO1
  • SCO5
  • SOW3
  • Ssm
  • Tr-kit
  • W
Alternatives
anti-Human KIT antibody for Immunofluorescence
Epitope
C-Term
89
65
40
36
32
24
22
22
14
14
13
13
13
13
13
12
12
10
9
9
9
9
9
9
9
9
9
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6
6
6
6
6
6
6
6
6
6
6
6
5
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
813
389
130
21
19
16
15
14
2
Host
Rabbit
631
232
207
4
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This KIT antibody is un-conjugated
107
90
84
71
49
41
15
15
11
11
8
8
8
8
8
8
7
6
5
5
4
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
380
350
349
174
137
108
89
59
46
37
29
13
11
11
8
4
4
3
2
2
2
2
2
2
Supplier
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Clone YR145
Isotype IgG
Specificity This antibody reacts to CD117.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Supernatant
Alternative Name CD117 / C-Kit (KIT Antibody Abstract)
Background CD117, c-kit is a tyrosine kinase receptor found on interstitial cells of Cajal, germ cells, bone marrow stem cells, melanocytes, breast epithelium and mast cells. This receptor is found on a wide variety of tumor cells (follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, breast, malignant melanoma, endodermal sinus tumor, and small cell carcinoma) but has been particularly useful in differentiating gastrointestinal stromal tumors from Kaposi's sarcoma, and tumors of smooth muscle origin.Synonyms: KIT, Mast/stem cell growth factor receptor, Proto-Oncogene Tyrosine-Protein Kinase, SCFR
Gene ID 3815
NCBI Accession NP_000213
UniProt P10721
Research Area CD Antigens, Surface Receptors of Immune Cells, Growth Factors, Receptors, Proliferation Markers
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer PBS, pH 7.4, 0,09 % sodium azide, 0,9 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications de Silva, Reid: "Gastrointestinal stromal tumors (GIST): C-kit mutations, CD117 expression, differential diagnosis and targeted cancer therapy with Imatinib." in: Pathology oncology research : POR, Vol. 9, Issue 1, pp. 13-9, 2003

Naeem, Dahiya, Clark, Creech, Alkan: "Analysis of c-kit protein expression in small-cell lung carcinoma and its implication for prognosis." in: Human pathology, Vol. 33, Issue 12, pp. 1182-7, 2003

Chen, Yanuck, Abbondanzo, Chu, Aguilera: "c-Kit (CD117) reactivity in extramedullary myeloid tumor/granulocytic sarcoma." in: Archives of pathology & laboratory medicine, Vol. 125, Issue 11, pp. 1448-52, 2001

Graadt van Roggen, van Velthuysen, Hogendoorn: "The histopathological differential diagnosis of gastrointestinal stromal tumours." in: Journal of clinical pathology, Vol. 54, Issue 2, pp. 96-102, 2001

Elmore, Domson, Moore, Kornstein, Burks: "Expression of c-kit (CD117) in benign and malignant human endometrial epithelium." in: Archives of pathology & laboratory medicine, Vol. 125, Issue 1, pp. 146-51, 2001

Miettinen, Sarlomo-Rikala, Sobin, Lasota: "Esophageal stromal tumors: a clinicopathologic, immunohistochemical, and molecular genetic study of 17 cases and comparison with esophageal leiomyomas and leiomyosarcomas." in: The American journal of surgical pathology, Vol. 24, Issue 2, pp. 211-22, 2000

Sircar, Hewlett, Huizinga, Chorneyko, Berezin, Riddell: "Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors." in: The American journal of surgical pathology, Vol. 23, Issue 4, pp. 377-89, 1999

Miettinen, Monihan, Sarlomo-Rikala, Kovatich, Carr, Emory, Sobin: "Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases." in: The American journal of surgical pathology, Vol. 23, Issue 9, pp. 1109-18, 1999

Kirschstein: "Editorial: cyclamates." in: Human pathology, Vol. 5, Issue 4, pp. 498-9, 1974