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Details for Product No. ABIN1105929

CD163 Molecule (CD163) antibody (PE)

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Antigen
Synonyms M130, MM130, CD163v2, CD163v3, DMBT1, CD163
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
Application
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS)
Pubmed 6 references available
Catalog no. ABIN1105929
Quantity 100 tests
Price
764.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Clone MAC2-48
Isotype IgG1
Specificity The antibody recognizes the CD163 antigen, which is present on all CD14+ monocytes, most CD64+ monocytes, and demonstrates higher expression on CD16+ monocytes.
Alternative Name CD163
Background The CD163 antigen is the cysteine-rich human scavenger receptor protein (p155, M130) found on mononuclear phagocytes, monocytes, and macrophages. CD163 is up-regulated on mononuclear phagocytes by IL-4, IL-6 and dexamethasone and serves as a receptor for the hemoglobin / haptoglobin complex. Expression of CD163 is restricted to cells of monocyte lineage and increases as the monocytes mature into macrophages. Stimulation of monocytes and macrophages by lipopolysacharide (LPS), IL-10, and tumor necrosis factor alpha (TNF-alpha) causes shedding of CD163 from the cell surface into plasma or supernatant.
Alternate names: Hemoglobin scavenger receptor, M130, Macrophage marker, Scavenger receptor cysteine- rich type 1 protein M130
Gene ID 9332
NCBI Accession NP_004235
UniProt Q86VB7
Research Area Cardiovascular, Atherosclerosis, CD Antigens, Innate Immunity, Surface Receptors of Immune Cells
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.2% BSA and 0.09% sodium azide
Preservative Sodium azide
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C. Fluorochrome labelled product is photosensitive and should be protected from light.
Expiry Date 12 months
Background publications Buechler, Ritter, Orsó et al.: "Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli." in: Journal of leukocyte biology, Vol. 67, Issue 1, pp. 97-103, 2000 (PubMed).

Sulahian, Högger, Wahner et al.: "Human monocytes express CD163, which is upregulated by IL-10 and identical to p155." in: Cytokine, Vol. 12, Issue 9, pp. 1312-21, 2000 (PubMed).

Madsen, Møller, Nielsen et al.: "Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region." in: The Journal of biological chemistry, Vol. 279, Issue 49, pp. 51561-7, 2004 (PubMed).

Moestrup, Møller: "CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response." in: Annals of medicine, Vol. 36, Issue 5, pp. 347-54, 2004 (PubMed).

Lau, Chu, Weiss: "CD163: a specific marker of macrophages in paraffin-embedded tissue samples." in: American journal of clinical pathology, Vol. 122, Issue 5, pp. 794-801, 2004 (PubMed).

Davis, Zarev: "Human monocyte CD163 expression inversely correlates with soluble CD163 plasma levels." in: Cytometry. Part B, Clinical cytometry, Vol. 63, Issue 1, pp. 16-22, 2005 (PubMed).

Alternatives for antigen "CD163 Molecule (CD163)", type "Antibodies"
Hosts (118), (48), (2)
Reactivities (142), (36), (24), (17), (17), (17), (6), (2), (1)
Applications (103), (65), (64), (39), (28), (24), (22), (14), (12), (10), (6), (4), (4), (3), (1)
Conjugates (21), (14), (12), (5), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (2), (2), (1), (1)
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