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CD19 Molecule (CD19) antibody (APC)

Details for Product No. ABIN1105975
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Antigen
Synonyms CD19, AW495831, B4, CVID3
Reactivity
Human
(422), (289), (46), (41), (41), (24), (24), (2)
Host
Mouse
(356), (149), (147), (3), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
APC
(77), (60), (60), (41), (15), (11), (10), (10), (9), (8), (8), (7), (7), (7), (7), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(463), (103), (89), (67), (58), (58), (49), (43), (27), (26), (14), (1), (1), (1)
Pubmed 2 references available
Quantity 100 tests
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN1105975
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Clone HD37
Isotype IgG1
Specificity Clone HD37 is specific for CD19, it recognizes a 95 kD transmembrane glycoprotein. Testing by flow cytometry using a 'lyse-wash' method on whole blood from healthy donors showed the following values expressed in terms of % of the total lymphocyte count: Product code: AM39014AC-N (anti-CD19 APC) n: 9 Mean % positive: 9,16 S.D.: 1,95 % CV: 21,31 ------------------------------------------ Product code: AM39014FC-N (anti-CD19 FITC) n: 9 Mean % positive: 10,80 S.D.: 2,14 % CV: 19,79 ------------------------------------------ Product code: AM39014RP-N (anti-CD19 PE) n: 9 Mean % positive: 10,57 S.D.: 2,06 % CV: 19,49 ------------------------------------------
Purification Affinity chromatography
Alternative Name CD19
Background Progenitor B cells mature in bone marrow and subsequently appear as mature CD19+ B cells in blood. After contact with foreign antigens and the appropriate T cell help, they may further differentiate to specific antibody-producing plasma cells.The function of the CD19 molecule is related to signal transfer and is involved in regulation of B cell proliferation. CD19 is considered to be a characteristic B cell marker and therefore commonly used in routine immunophenotyping. Detection of CD19 expressing cells is important in the diagnosis of leukemic precursor B cells (pre-B ALL), mature B cells (B ALL), and plasma cells. Distinction between subtypes of these (acute) leukemias can be performed using CD19 antibodies together with monoclonal antibodies to cytoplasmic or membrane Ig. A large number of B cell disorders can be effectively characterized by expression of CD19 and one or more additional antigens. One example is hairy cell leukemia (HCL), which shows specific expression of CD11c, CD19, CD20 and CD103. The combination CD103/CD19 is an important tool for diagnosis of HCL. Other valuable antibody combinations for distinction between different leukemias using CD19 antibodies are CD5/CD19 (e.g. Chronic Lymphatic Leukemia), CD10/CD19 (common ALL and pre-B ALL) and CD19/cyCD79a (Acute B cell leukemia). CD19 may also be expressed on follicular dendritic cells.
Alternate names: B-cell marker, B-lymphocyte surface antigen B4, Differentiation antigen CD19, Leu-12
Gene ID 930
NCBI Accession NP_001171569
UniProt P15391
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Restrictions For Research Use only
Format Liquid
Buffer 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2% BSA, 0.09% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C. Fluorochrome labelled product is photosensitive and should be protected from light.
Expiry Date 12 months
Supplier Images
anti-CD19 Molecule (CD19) antibody (APC) anti-CD19 Molecule (CD19) antibody (APC)
Background publications Loken, Shah, Dattilio et al.: "Flow cytometric analysis of human bone marrow. II. Normal B lymphocyte development." in: Blood, Vol. 70, Issue 5, pp. 1316-24, 1987 (PubMed).

Rothe, Schmitz: "Consensus protocol for the flow cytometric immunophenotyping of hematopoietic malignancies. Working Group on Flow Cytometry and Image Analysis." in: Leukemia, Vol. 10, Issue 5, pp. 877-95, 1996 (PubMed).

Validation Images
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