CCR3 antibody (FITC)

Catalog No. ABIN1105990

Product Details anti-CCR3 Antibody (FITC)

Target: CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CCR3 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Specificity: This antibody reacts with CD193 antigen. The antibody has also been reported to inhibit chemotactic migration of monocyte-derived DCs to RANTES (Ref.4). It suppresses the capacity of monocyte-derived DCs to stimulate allogenetic TCs proliferation and TCs derived IFN-γ secretion( Ref.4).

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein A agarose

Immunogen: Human CCR3 expressing transfectant (mouse pre-B cell lymphoma B300-19)

Clone: 444-11

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 50 tests in 1 mLvolume of 10 μM NaPB, 0.09 % NaN3, 1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

Target Details for CCR3

Target: CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

Alternative Name: CD193 / CCR3 (CCR3 Products)

Synonyms: CC-CKR-3 antibody, CD193 antibody, CKR3 antibody, CMKBR3 antibody, CC-CKR3 antibody, Cmkbr1l2 antibody, Cmkbr3 antibody, C-C motif chemokine receptor 3 antibody, chemokine (C-C motif) receptor 3 antibody, CCR3 antibody, Ccr3 antibody

Background: Dendritic cells (DCs) are major antigen presenting cells (APCs) capable of stimulation resting T cells (TCs) in the primary immune response and are more potent APCs than peripheral blood monocytes or B cells. Several CC and CXC chemokines receptors were found to be expressed on some DCs and these molecules have been implicated to mediate in part the trafficking of DCs from blood to tissues and then to lymph nodes, where they form a close association with TCs in the process of antigen presentation. Recent studies have shown that CD191/CCR1 and CD193/CCR3 are potentially involved in antigen-presenting cell function of human DCs.Synonyms: C-C CKR-3, C-C chemokine receptor type 3, CC-CKR-3, CCR-3, CKR3, CMKBR3, Eosinophil eotaxin receptor

Gene ID: 1232

NCBI Accession: NP_001828

UniProt: P51677