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Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2) antibody

Details for Product No. ABIN1106063, Supplier: Log in to see
Antigen
  • C3DR
  • CD21
  • CR
  • CVID7
  • SLEB9
  • cd21
  • Cd21
  • CD35
  • Cr-1
  • Cr-2
  • Cr1
Reactivity
Human
292
44
36
26
26
26
10
10
8
7
3
3
3
3
1
1
1
Host
Mouse
294
66
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
70
61
24
9
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
258
62
60
56
54
43
33
29
17
11
9
6
4
4
2
1
1
Supplier
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Clone 2G9
Isotype IgG2a
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Supernatant
Alternative Name CD21 (CR2 Antibody Abstract)
Background CD21, also known as CR2, C3d receptor and EBV receptor, is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.Synonyms: C3DR, C3d receptor, CR2, Complement C3d receptor, Complement receptor type 2, Dendritic Cell Marker, EBV Receptor, Epstein-Barr virus receptor
Gene ID 9606
UniProt P20023
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer PBS, pH 7.4, 0.09 % Sodium Azide, 0.9 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (IHC) image for anti-Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2) antibody (ABIN1106063) anti-Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2) antibody
Background publications Chang, Huang, Medeiros et al.: "Germinal centre-like versus undifferentiated stromal immunophenotypes in follicular lymphoma." in: The Journal of pathology, Vol. 201, Issue 3, pp. 404-12, 2003 (PubMed).

Herrmann, Cheevers, Davis et al.: "CD21-positive follicular dendritic cells: A possible source of PrPSc in lymph node macrophages of scrapie-infected sheep." in: The American journal of pathology, Vol. 162, Issue 4, pp. 1075-81, 2003 (PubMed).

Maeda, Matsuda, Suzuki et al.: "Immunohistochemical recognition of human follicular dendritic cells (FDCs) in routinely processed paraffin sections." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 50, Issue 11, pp. 1475-86, 2002 (PubMed).

Dillon, Hill, Cameron et al.: "Mediastinal mixed dendritic cell sarcoma with hybrid features." in: Journal of clinical pathology, Vol. 55, Issue 10, pp. 791-4, 2002 (PubMed).

Pileri, Grogan, Harris et al.: "Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases." in: Histopathology, Vol. 41, Issue 1, pp. 1-29, 2002 (PubMed).

Biddle, Ro, Yoon et al.: "Extranodal follicular dendritic cell sarcoma of the head and neck region: three new cases, with a review of the literature." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 15, Issue 1, pp. 50-8, 2002 (PubMed).

Chan, Chan, Chan et al.: "Development of follicular dendritic cell sarcoma in hyaline-vascular Castleman's disease of the nasopharynx: tracing its evolution by sequential biopsies." in: Histopathology, Vol. 38, Issue 6, pp. 510-8, 2001 (PubMed).

Cheuk, Chan, Shek et al.: "Inflammatory pseudotumor-like follicular dendritic cell tumor: a distinctive low-grade malignant intra-abdominal neoplasm with consistent Epstein-Barr virus association." in: The American journal of surgical pathology, Vol. 25, Issue 6, pp. 721-31, 2001 (PubMed).