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Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2) antibody

Details for Product No. ABIN1106063, Supplier: Log in to see
Antigen
  • C3DR
  • Cd21
  • cd21
  • CD21
  • CD35
  • CR
  • Cr-1
  • Cr-2
  • Cr1
  • CVID7
  • SLEB9
Reactivity
Human
358
57
36
27
26
26
20
10
10
8
3
3
3
3
1
1
1
Host
Mouse
368
71
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
72
65
26
9
7
6
5
5
5
5
4
4
4
4
4
4
4
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
333
92
74
72
64
42
35
34
17
11
9
6
4
4
2
1
1
Supplier
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Clone 2G9
Isotype IgG2a
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Supernatant
Alternative Name CD21 (CR2 Antibody Abstract)
Background CD21, also known as CR2, C3d receptor and EBV receptor, is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.Synonyms: C3DR, C3d receptor, CR2, Complement C3d receptor, Complement receptor type 2, Dendritic Cell Marker, EBV Receptor, Epstein-Barr virus receptor
Gene ID 9606
UniProt P20023
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer PBS, pH 7.4, 0.09 % Sodium Azide, 0.9 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (IHC) image for anti-Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2) antibody (ABIN1106063) anti-Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2) antibody
Background publications Herrmann, Cheevers, Davis, Knowles, ORourke: "CD21-positive follicular dendritic cells: A possible source of PrPSc in lymph node macrophages of scrapie-infected sheep." in: The American journal of pathology, Vol. 162, Issue 4, pp. 1075-81, 2003 (PubMed).

Chang, Huang, Medeiros, Jones: "Germinal centre-like versus undifferentiated stromal immunophenotypes in follicular lymphoma." in: The Journal of pathology, Vol. 201, Issue 3, pp. 404-12, 2003 (PubMed).

Dillon, Hill, Cameron, Attanoos, McCluggage: "Mediastinal mixed dendritic cell sarcoma with hybrid features." in: Journal of clinical pathology, Vol. 55, Issue 10, pp. 791-4, 2002 (PubMed).

Maeda, Matsuda, Suzuki, Saitoh: "Immunohistochemical recognition of human follicular dendritic cells (FDCs) in routinely processed paraffin sections." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 50, Issue 11, pp. 1475-86, 2002 (PubMed).

Pileri, Grogan, Harris, Banks, Campo, Chan, Favera, Delsol, De Wolf-Peeters, Falini, Gascoyne, Gaulard, Gatter, Isaacson, Jaffe, Kluin, Knowles, Mason, Mori, Müller-Hermelink, Piris, Ralfkiaer, Stein, Su, Warnke, Weiss: "Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases." in: Histopathology, Vol. 41, Issue 1, pp. 1-29, 2002 (PubMed).

Biddle, Ro, Yoon, Yong, Ayala, Ordonez, Ro: "Extranodal follicular dendritic cell sarcoma of the head and neck region: three new cases, with a review of the literature." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 15, Issue 1, pp. 50-8, 2002 (PubMed).

Cheuk, Chan, Shek, Chang, Tsou, Yuen, Ng, Chan, Prat: "Inflammatory pseudotumor-like follicular dendritic cell tumor: a distinctive low-grade malignant intra-abdominal neoplasm with consistent Epstein-Barr virus association." in: The American journal of surgical pathology, Vol. 25, Issue 6, pp. 721-31, 2001 (PubMed).

Chan, Chan, Chan, Au, Ho, Ng: "Development of follicular dendritic cell sarcoma in hyaline-vascular Castleman's disease of the nasopharynx: tracing its evolution by sequential biopsies." in: Histopathology, Vol. 38, Issue 6, pp. 510-8, 2001 (PubMed).