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IGF1R antibody (Insulin-Like Growth Factor 1 Receptor)

Details for Product anti-IGF1R Antibody No. ABIN1106090, Supplier: Login to see New
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Synonyms IGF1R, DKFZp469I0618, igf-1r, xIGF-1R, xIGFR, xigf1r, CD221, IGFIR, IGFR, JTK13, IGFIRC, IGF-1R, IGFR1, A330103N21Rik, D930020L01, hyft
(444), (172), (170), (2), (2), (2), (2), (1), (1)
(302), (135), (3), (3)
Clonality (Clone)
Monoclonal ()
This IGF1R antibody is un-conjugated
(19), (18), (18), (16), (10), (9), (8), (8), (8), (8), (8), (8), (8), (8), (6)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(276), (112), (104), (88), (74), (58), (40), (30), (9), (9), (7), (6), (4), (3), (2), (1), (1), (1), (1)
Pubmed 3 references available
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Quantity 0.1 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Clone 3C8B1
Isotype IgG2b
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name CD221 / IGF1R (IGF1R Antibody Abstract)
Background IGF1R (insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.Synonyms: IGF-I receptor, IGF1 Receptor, Insulin-like growth factor 1 receptor
Gene ID 3480
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways RTK Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Immunohistochemistry (IHC) image for anti-IGF1R antibody (Insulin-Like Growth Factor 1 Receptor) (ABIN1106090) anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) antibody
Western Blotting (WB) image for anti-IGF1R antibody (Insulin-Like Growth Factor 1 Receptor) (ABIN1106090) anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) antibody (Image 2)
Background publications Baserga: "The contradictions of the insulin-like growth factor 1 receptor." in: Oncogene, Vol. 19, Issue 49, pp. 5574-81, 2000 (PubMed).

Scheidegger, Cenni, Picard et al.: "Estradiol decreases IGF-1 and IGF-1 receptor expression in rat aortic smooth muscle cells. Mechanisms for its atheroprotective effects." in: The Journal of biological chemistry, Vol. 275, Issue 49, pp. 38921-8, 2001 (PubMed).

Adams, Epa, Garrett et al.: "Structure and function of the type 1 insulin-like growth factor receptor." in: Cellular and molecular life sciences : CMLS, Vol. 57, Issue 7, pp. 1050-93, 2000 (PubMed).

Catalog No. ABIN1106090
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