ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) antibody

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Antigen
  • MDR1
  • xemdr
  • ABC20
  • CD243
  • CLCS
  • GP170
  • P-GP
  • PGY1
  • p-gp
  • Abcb1
  • Mdr1a
  • ABCB1
  • PGP1
  • Mdr1
  • Mdr1b
  • Pgy-1
  • Pgy1
  • mdr
  • Mdr
  • Cd243
  • Mdr-1
  • Mod-2
  • Mod-2r
  • Mod-2s
  • Mod2-r
  • Mod2-s
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1A
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B
  • ATP-binding cassette, subfamily B (MDR/TAP), member 1B
  • malic enzyme complex, mitochondrial
  • ABCB1
  • abcb1
  • Abcb1a
  • Abcb1b
  • Mod2
Reactivity
Human
268
28
18
14
10
8
8
2
2
1
1
1
1
1
1
1
1
1
Host
Mouse
182
97
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
14
9
9
7
5
5
4
4
4
4
4
4
4
4
4
3
2
2
2
2
2
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
139
82
75
74
37
34
24
22
8
6
5
3
3
3
2
2
2
1
Options
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Immunogen A mixture of human and hamster drug-resistant whole cells and crude plasma membranes.
Clone PG-13
Isotype IgG1
Specificity This antibody reacts to CD243 / MDR1.
Purification Affinity chromatography
Alternative Name CD243 / MDR1 (ABCB1 Antibody Abstract)
Background P-Glycoprotein, also known as Multidrug Resistance 1 (MDR1), is one of the ATP-binding cassette transporters family. P-glycoprotein-1 is involved in the transport of 3 of these protease inhibitors in vitro.MDR1 gene is mapped to the 7q21.1 by in situ hybridization. The MDR1 gene product, P-glycoprotein,mediates the transport of the cardiac glycoside, digoxin.Synonyms: ABCB1, ATP-binding cassette sub-family B member 1, Multidrug resistance protein 1, P-glycoprotein 1, PGY1
Gene ID 5243
NCBI Accession NP_000918
UniProt P08183
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Reconstitution Restore with 1.2 % sodium acetate or neutral PBS
Concentration 0,1 mg/mL
Buffer 1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications de Lannoy, Silverman: "The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin." in: Biochemical and biophysical research communications, Vol. 189, Issue 1, pp. 551-7, 1992 (PubMed).

Callen, Baker, Simmers, Seshadri, Roninson: "Localization of the human multiple drug resistance gene, MDR1, to 7q21.1." in: Human genetics, Vol. 77, Issue 2, pp. 142-4, 1987 (PubMed).