anti-NGFR antibody (Nerve Growth Factor Receptor)

Details for Product anti-NGFR Antibody No. ABIN1106176
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Synonyms ngfr, wu:fb38c02, wu:fc10h01, CD271, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR, LNGFR, RNNGFRR, Tnfrsf16, p75, NRH1b, fullback, nrh1, p75ntr, tnfrsf16, p75NGFR
(238), (96), (86), (8), (8), (6), (6), (5), (5), (4), (4), (1), (1), (1), (1), (1), (1)
(139), (94), (33), (4), (1)
Clonality (Clone)
Monoclonal ()
This NGFR antibody is un-conjugated
(18), (16), (11), (10), (6), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
(184), (106), (73), (69), (50), (32), (31), (29), (20), (18), (10), (7), (6), (6), (4), (4), (2), (1), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Clone 2F1C2
Isotype IgG1
Specificity This antibody reacts to NGFR.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name CD271 / NGFR (NGFR Antibody Abstract)
Background Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGFR p75 plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of NGFR p75 by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE like proteases and the JNK pathway. In rat Schwann cells, NGF binding to NGFR p75 activates NF kappaB, possibly to modulate Schwann cell migration during nerve regeneration. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells).Synonyms: TNFRSF16, Tumor necrosis factor receptor superfamily member 16
Molecular Weight 45 kDa
Gene ID 4804
Research Area Growth Factors, Receptors
Pathways NF-kappaB Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Flow Cytometry (FACS) image for anti-NGFR antibody (Nerve Growth Factor Receptor) (ABIN1106176) anti-Nerve Growth Factor Receptor (NGFR) antibody
Immunofluorescence (IF) image for anti-NGFR antibody (Nerve Growth Factor Receptor) (ABIN1106176) anti-Nerve Growth Factor Receptor (NGFR) antibody (Image 2)
Western Blotting (WB) image for anti-NGFR antibody (Nerve Growth Factor Receptor) (ABIN1106176) anti-Nerve Growth Factor Receptor (NGFR) antibody (Image 3)
Background publications He, Garcia: "Structure of nerve growth factor complexed with the shared neurotrophin receptor p75." in: Science (New York, N.Y.), Vol. 304, Issue 5672, pp. 870-5, 2004 (PubMed).

Hu, Zhang, Qin et al.: "Increased p75(NTR) expression in hippocampal neurons containing hyperphosphorylated tau in Alzheimer patients." in: Experimental neurology, Vol. 178, Issue 1, pp. 104-11, 2002 (PubMed).

DiDonato, Hayakawa, Rothwarf et al.: "A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB." in: Nature, Vol. 388, Issue 6642, pp. 548-54, 1997 (PubMed).

Fantini, Johansson: "Expression of growth-associated protein 43 and nerve growth factor receptor in human skin: a comparative immunohistochemical investigation." in: The Journal of investigative dermatology, Vol. 99, Issue 6, pp. 734-42, 1993 (PubMed).

Catalog No. ABIN1106176
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