Nerve Growth Factor Receptor (NGFR) antibody

Details for Product No. ABIN1106176
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Antigen
Synonyms ngfr, wu:fb38c02, wu:fc10h01, CD271, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR, LNGFR, RNNGFRR, Tnfrsf16, p75, NRH1b, fullback, nrh1, p75ntr, tnfrsf16, p75NGFR
Reactivity
Human
(148), (75), (72), (29), (14), (13), (13), (8), (7), (5), (3), (3), (1), (1), (1), (1)
Host
Mouse
(108), (50), (11), (4), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(10), (5), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
(126), (58), (45), (41), (37), (31), (27), (20), (20), (19), (10), (6), (4), (3), (1), (1), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN1106176
390.50 $
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Clone 2F1C2
Isotype IgG1
Specificity This antibody reacts to NGFR.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name CD271 / NGFR
Background Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGFR p75 plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of NGFR p75 by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE like proteases and the JNK pathway. In rat Schwann cells, NGF binding to NGFR p75 activates NF kappaB, possibly to modulate Schwann cell migration during nerve regeneration. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells).Synonyms: TNFRSF16, Tumor necrosis factor receptor superfamily member 16
Molecular Weight 45 kDa
Gene ID 4804
Research Area Growth Factors, Receptors
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
anti-Nerve Growth Factor Receptor (NGFR) antibody anti-Nerve Growth Factor Receptor (NGFR) antibody
anti-Nerve Growth Factor Receptor (NGFR) antibody (2) anti-Nerve Growth Factor Receptor (NGFR) antibody (Image 2)
anti-Nerve Growth Factor Receptor (NGFR) antibody (3) anti-Nerve Growth Factor Receptor (NGFR) antibody (Image 3)
Background publications Fantini, Johansson: "Expression of growth-associated protein 43 and nerve growth factor receptor in human skin: a comparative immunohistochemical investigation." in: The Journal of investigative dermatology, Vol. 99, Issue 6, pp. 734-42, 1993 (PubMed).

DiDonato, Hayakawa, Rothwarf et al.: "A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB." in: Nature, Vol. 388, Issue 6642, pp. 548-54, 1997 (PubMed).

Hu, Zhang, Qin et al.: "Increased p75(NTR) expression in hippocampal neurons containing hyperphosphorylated tau in Alzheimer patients." in: Experimental neurology, Vol. 178, Issue 1, pp. 104-11, 2002 (PubMed).

He, Garcia: "Structure of nerve growth factor complexed with the shared neurotrophin receptor p75." in: Science (New York, N.Y.), Vol. 304, Issue 5672, pp. 870-5, 2004 (PubMed).

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