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PD-L1 antibody (CD274 Molecule) (Biotin)

Details for Product anti-CD274 Antibody No. ABIN1106178, Supplier: Log in to see
Antigen
Reactivity
Human
193
93
21
1
1
Host
Mouse
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90
59
19
2
Clonality (Clone)
Monoclonal ()
Conjugate
This PD-L1 antibody is conjugated to Biotin
23
19
19
12
6
3
3
3
2
2
2
1
1
Application
Flow Cytometry (FACS)
126
116
80
42
16
16
15
8
6
4
3
3
2
2
2
2
2
2
2
1
1
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Immunogen Full-length human PD-L1 transfected L cells
Clone MIH3
Isotype IgG1
Specificity This antibody reacts with human CD274.
Purification Protein A agarose
Alternative Name CD274 / PDL1 (CD274 Antibody Abstract)
Background Programmed death ligand 1 (PD-L1, also known as CD274/B7-H1), a member of B7 family was identified by searching for molecules that share homology with the immunoglobulin V and C domains of B7-1 and B7-2 among the human cDNA expressed sequence tags in the National Center for Biotechnology Information database. PD-L1 is a ligand for programmed death 1 (PD-1) which belongs to the CD28/CTLA4 subfamily. Although in vitro study indicated that the cross-linking of PD-1 by PD-L1 leads to down-regulation of T-cell responses, some studies have shown that T cells stimulated with low levels of anti-CD3 and immobilized PD-L1-Ig were activated, proliferation and production of IFN-γ, GM-CSF and IL-10 from the T cells were enhanced.Synonyms: B7 homolog 1, B7H1, PD-L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, Programmed cell death 1 ligand 1, Programmed death ligand 1
Gene ID 29126
NCBI Accession NP_054862
UniProt Q9NZQ7
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.02 mg/mL
Buffer PBS, 0.09 % NaN3, 1 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 2 - 8 °C.
Supplier Images
Flow Cytometry (FACS) image for anti-PD-L1 antibody (CD274 Molecule)  (Biotin) (ABIN1106178) anti-CD274 Molecule (CD274) antibody (Biotin)
Background publications del Rio, Rodriguez-Barbosa, Kremmer et al.: "CD103- and CD103+ bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 11, pp. 6861-6, 2007 (PubMed).

Yamazaki, Akiba, Iwai et al.: "Expression of programmed death 1 ligands by murine T cells and APC." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 10, pp. 5538-45, 2002 (PubMed).