Toll-Like Receptor 1 (TLR1) antibody

Details for Product No. ABIN1106186
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Synonyms CD281, TIL, TIL. LPRS5, rsc786
(173), (73), (28)
(124), (57), (11), (8)
Clonality (Clone)
Monoclonal ()
(17), (15), (15), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Functional Studies (Func), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(114), (73), (60), (50), (28), (18), (17), (13), (10), (7), (6), (5), (3), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen TLR1Fc
Clone GD2-F4
Isotype IgG1
Specificity The monoclonal antibody GD2.F4 reacts with human TLR1. Does not react with TLR2 or TLR4.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein G
Alternative Name CD281 / TLR1 (TLR1 Antibody Abstract)
Background Toll-like receptors (TLR) are highly conserved throughout evolution and play an essential role in recognizing conserved motifs found in various pathogens and initiating an appropriate innate immune response. In human, ten members of the TLR family have been identified as type I transmembrane signaling receptors containing multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Mammalian responsiveness to microbial products may be mediated by combinations of TLRs, for example a co-operative effect is observed between TLR1 and TLR2 in response to bacterial lipoproteins. On the other hand, TLR 1 was shown to have the capacity to abrogate TLR4 signaling. In general, TLR1 is expressed at higher levels as compared to other TLRs. The highest expression of TLR1 is found in monocytes but it can also be expressed by macrophages, dendritic cells, B, T, and NK cells. In recent studies, several human TLR1 polymorphisms have been associated with impaired mycobacterial signaling and susceptibility to tuberculosis.Synonyms: KIAA0012, TIL, Toll-like receptor 1, Toll/interleukin-1 receptor-like protein
Gene ID 9606
UniProt Q15399
Research Area Signaling, Immunology, Inflammation
Pathways TLR Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.1 % BSA
Storage 4 °C
Storage Comment Store at 2 - 8 °C.
Background publications Panda, Qian, Mohanty et al.: "Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 5, pp. 2518-27, 2010 (PubMed).

Sandor, Latz, Re et al.: "Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling." in: The Journal of cell biology, Vol. 162, Issue 6, pp. 1099-110, 2003 (PubMed).

Ochoa, Legaspi, Hatziris et al.: "Distribution of Toll-like receptor 1 and Toll-like receptor 2 in human lymphoid tissue." in: Immunology, Vol. 108, Issue 1, pp. 10-5, 2003 (PubMed).

Visintin, Mazzoni, Spitzer et al.: "Regulation of Toll-like receptors in human monocytes and dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 249-55, 2001 (PubMed).

Wyllie, Kiss-Toth, Visintin et al.: "Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 12, pp. 7125-32, 2000 (PubMed).

Catalog No. ABIN1106186
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