Toll-Like Receptor 2 (TLR2) antibody (Biotin)

Details for Product No. ABIN1106199
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Antigen
Synonyms TIL4, CD282, Ly105
Reactivity
Dog (Canine), Human
(275), (120), (17), (16), (13), (13), (12), (3), (1), (1), (1)
Host
Mouse
(225), (75), (34), (5), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Biotin
(40), (39), (26), (6), (5), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), ELISA
(194), (125), (92), (71), (43), (40), (30), (29), (24), (24), (20), (10), (3), (1), (1), (1), (1)
Pubmed 6 references available
Catalog no. ABIN1106199
Quantity 50 µg
Price
379.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days

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Clone TL2-3
Isotype IgG2a
Specificity The TL2.3 monoclonal antibody is specific for human TLR2 (CD282). TL2.3 is useful for studies on the role of TLR2 as a pattern recognition receptor in microbial products induced cytokine production by TLR2 bearing cells such as human peripheral blood mononuclear
Purification Protein G
Alternative Name CD282 / TLR2
Background Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR2 has been identified as a receptor that is central to the innate immune response to lipoproteins of Gram-negative bacteria, several whole Gram-positive bacteria, as well as a receptor for peptidoglycan and lipoteichoic acid and other bacterial cell membrane products. A functional interaction between TLR2 and TLR6 in the cellular response to various bacterial products has been discovered. The currently accepted paradigm regards TLR2 as an essential receptor for many eubacterial cell wall components, including lipoproteins and peptidoglycan. Bacterial species as diverse as mycobacteria, spirochetes, mycoplasma, Staphylococcus aureus, and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2 (CD282).
Alternate names: Toll-like receptor 2
NCBI Accession 9606
UniProt O60603
Research Area Signaling, Immunology, Inflammation
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer PBS, 0.02% sodium azide, 0.1% bovine serum albumin
Preservative Sodium azide
Storage 4 °C
Storage Comment Store at 2 - 8 °C.
Expiry Date 12 months
Background publications Lien, Sellati, Yoshimura et al.: "Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products." in: The Journal of biological chemistry, Vol. 274, Issue 47, pp. 33419-25, 1999 (PubMed).

Lien, Chow, Hawkins et al.: "A novel synthetic acyclic lipid A-like agonist activates cells via the lipopolysaccharide/toll-like receptor 4 signaling pathway." in: The Journal of biological chemistry, Vol. 276, Issue 3, pp. 1873-80, 2001 (PubMed).

Faure, Thomas, Xu et al.: "Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 3, pp. 2018-24, 2001 (PubMed).

Wang, Warris, Ellingsen et al.: "Involvement of CD14 and toll-like receptors in activation of human monocytes by Aspergillus fumigatus hyphae." in: Infection and immunity, Vol. 69, Issue 4, pp. 2402-6, 2001 (PubMed).

Flo, Halaas, Torp et al.: "Differential expression of Toll-like receptor 2 in human cells." in: Journal of leukocyte biology, Vol. 69, Issue 3, pp. 474-81, 2001 (PubMed).

Burgener, Jungi: "Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry." in: Veterinary immunology and immunopathology, Vol. 124, Issue 1-2, pp. 184-91, 2008 (PubMed).

Hosts (225), (75), (34), (5), (4)
Reactivities (275), (120), (17), (16), (13), (13), (12), (3), (1), (1), (1)
Applications (194), (125), (92), (71), (43), (40), (30), (29), (24), (24), (20), (10), (3), (1), (1), (1), (1)
Conjugates (40), (39), (26), (6), (5), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (21), (14), (6), (5), (5), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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