VEGFR2 antibody (Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase))

Details for Product anti-KDR Antibody No. ABIN1106249, Supplier: Log in to see
Antigen
  • vegfr-2
  • KDR
  • 6130401C07
  • Flk-1
  • Flk1
  • Krd-1
  • Ly73
  • VEGFR-2
  • VEGFR2
  • sVEGFR-2
  • Vegfr-2
  • CD309
  • FLK1
  • VEGFR
  • FLK-1
  • flk-1
  • FLK/KDR
  • flk1
  • flk1b
  • kdrb
  • si:busm1-205d10.1
  • si:ch211-254j6.1
  • si:ch211-278f21.4
  • wu:fc31a09
  • fk52c05
  • flk
  • kdr
  • kdra
  • vegfr2
  • vegfr4
  • vegr2
  • wu:fk52c05
  • vascular endothelial growth factor receptor 2
  • kinase insert domain protein receptor
  • kinase insert domain receptor
  • kinase insert domain receptor (a type III receptor tyrosine kinase)
  • kinase insert domain receptor like
  • vascular endothelial growth factor receptor-2
  • vegfr-2
  • Kdr
  • KDR
  • kdr
  • kdrl
Alternatives
anti-Human VEGFR2 antibody for Blocking Antibody
Reactivity
Human
611
372
183
25
7
4
4
4
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3
2
2
1
1
1
1
1
1
1
1
Host
Mouse
535
140
60
4
2
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This VEGFR2 antibody is un-conjugated
45
32
24
20
18
12
11
9
9
5
5
5
5
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4
3
3
3
3
3
3
3
3
3
3
3
3
2
2
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2
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
462
239
208
201
117
109
40
34
26
24
18
17
11
9
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5
3
2
1
1
1
1
1
1
1
Options
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Clone 4B4
Isotype IgG1
Specificity This antibody recognizes Human VEGFR-2 / KDR. Other species not tested.
Purification Ascites
Alternative Name CD309 / VEGFR-2 / Flk-1 (KDR Antibody Abstract)
Background KDR has also been designated as VEGFR-2 (Vascular endothelial growth factor receptor 2), CD309 (cluster of differentiation 309) and Flk-1 (fetal liver kinase 1). Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. KDR is one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.Synonyms: FLK1, KDR, Kinase NYK, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, VEGF Receptor 2, VEGFR2, Vascular endothelial growth factor receptor 2
Molecular Weight 152 kDa
Gene ID 3791
Research Area Cytokines, Receptors
Pathways RTK Signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Flow Cytometry (FACS) image for anti-VEGFR2 antibody (Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase)) (ABIN1106249) anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) antibody
Immunofluorescence (IF) image for anti-VEGFR2 antibody (Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase)) (ABIN1106249) anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) antibody (Image 2)
Western Blotting (WB) image for anti-VEGFR2 antibody (Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase)) (ABIN1106249) anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) antibody (Image 3)
Background publications Cartron, Moreau, Oliver, Mayat, Meflah, Vallette: "Involvement of the N-terminus of Bax in its intracellular localization and function." in: FEBS letters, Vol. 512, Issue 1-3, pp. 95-100, 2002 (PubMed).

Selheim, Holmsen, Vassbotn: "Identification of functional VEGF receptors on human platelets." in: FEBS letters, Vol. 512, Issue 1-3, pp. 107-10, 2002 (PubMed).

Takahashi, Yamaguchi, Chida, Shibuya: "A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells." in: The EMBO journal, Vol. 20, Issue 11, pp. 2768-78, 2001 (PubMed).