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VEGFR2 antibody (Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase))

Details for Product anti-KDR Antibody No. ABIN1106249, Supplier: Login to see
Antigen
  • vegfr-2
  • KDR
  • 6130401C07
  • Flk-1
  • Flk1
  • Krd-1
  • Ly73
  • VEGFR-2
  • VEGFR2
  • sVEGFR-2
  • Vegfr-2
  • CD309
  • FLK1
  • VEGFR
  • FLK-1
  • flk-1
  • FLK/KDR
  • flk1
  • flk1b
  • kdrb
  • si:busm1-205d10.1
  • si:ch211-254j6.1
  • si:ch211-278f21.4
  • wu:fc31a09
  • fk52c05
  • flk
  • kdr
  • kdra
  • vegfr2
  • vegfr4
  • vegr2
  • wu:fk52c05
Alternatives
anti-Human VEGFR2 antibody for Immunohistochemistry (Frozen Sections)
Reactivity
Human
509
235
135
5
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Host
Mouse
462
99
23
3
2
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This VEGFR2 antibody is un-conjugated
34
21
16
14
12
11
3
3
3
3
3
3
3
3
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
399
232
207
111
95
94
40
24
24
20
17
15
8
6
6
2
1
1
Supplier
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Clone 4B4
Isotype IgG1
Specificity This antibody recognizes Human VEGFR-2 / KDR. Other species not tested.
Purification Ascites
Alternative Name CD309 / VEGFR-2 / Flk-1 (KDR Antibody Abstract)
Background KDR has also been designated as VEGFR-2 (Vascular endothelial growth factor receptor 2), CD309 (cluster of differentiation 309) and Flk-1 (fetal liver kinase 1). Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. KDR is one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.Synonyms: FLK1, KDR, Kinase NYK, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, VEGF Receptor 2, VEGFR2, Vascular endothelial growth factor receptor 2
Molecular Weight 152 kDa
Gene ID 3791
Research Area Cytokines, Receptors
Pathways RTK Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Flow Cytometry (FACS) image for anti-VEGFR2 antibody (Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase)) (ABIN1106249) anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) antibody
Immunofluorescence (IF) image for anti-VEGFR2 antibody (Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase)) (ABIN1106249) anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) antibody (Image 2)
Western Blotting (WB) image for anti-VEGFR2 antibody (Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase)) (ABIN1106249) anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) antibody (Image 3)
Background publications Selheim, Holmsen, Vassbotn: "Identification of functional VEGF receptors on human platelets." in: FEBS letters, Vol. 512, Issue 1-3, pp. 107-10, 2002 (PubMed).

Cartron, Moreau, Oliver et al.: "Involvement of the N-terminus of Bax in its intracellular localization and function." in: FEBS letters, Vol. 512, Issue 1-3, pp. 95-100, 2002 (PubMed).

Takahashi, Yamaguchi, Chida et al.: "A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells." in: The EMBO journal, Vol. 20, Issue 11, pp. 2768-78, 2001 (PubMed).