Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A) antibody

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Antigen
  • CD32
  • CD32A
  • CDw32
  • FCG2
  • FCGR2
  • FCGR2A1
  • FcGR
  • IGFR2
  • CD32a
  • Fc fragment of IgG, low affinity IIa, receptor (CD32)
  • FCGR2A
Reactivity
Dog (Canine), Human, Rhesus Monkey
179
9
8
7
4
3
3
2
1
Host
Mouse
126
63
4
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
11
11
9
5
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
Application
Functional Studies (Func), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunoprecipitation (IP)
96
93
46
40
32
23
18
5
4
3
3
1
1
1
1
1
1
Options
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Immunogen K562 cell line
Clone AT10
Isotype IgG1
Purification Affinity Chromatography on Protein A
Endotoxin Level Low Endotoxin
Alternative Name CD32 / FcRII-A (FCGR2A Antibody Abstract)
Background CD32 antigen is a 40 kD glycoprotein that acts as a low affinity receptor for IgG (also known as Fc gamma RII). The antigen mediates several functions including endocytosis, activation of secretion, cytotoxicity and immunomodulation. CD32 is expressed by B cells, monocytes, granulocytes and platelets.Synonyms: CDw32, FCG2, FCGR2A, FCGR2A1, Fc-gamma RII-a, Fc-gamma-RIIa, IGFR2, IgG Fc receptor II, Low affinity immunoglobulin gamma Fc region receptor II
Gene ID 2212
NCBI Accession NP_001129691
UniProt P12318
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS without preservatives
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.
Background publications Zhao, van Beek, Schornagel, Van der Maaden, Van Houdt, Otten, Finetti, Van Egmond, Matozaki, Kraal, Birnbaum, van Elsas, Kuijpers, Bertucci, van den Berg: "CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 45, pp. 18342-7, 2011 (PubMed).

Araújo, de Andrade, Sathler-Avelar, Magalhães, Carvalho, Andrade, Campolina, Mello, Vianna, Mayrink, Reis, Malaquias, Rocha, Martins-Filho: "Immunological changes in canine peripheral blood leukocytes triggered by immunization with first or second generation vaccines against canine visceral leishmaniasis." in: Veterinary immunology and immunopathology, Vol. 141, Issue 1-2, pp. 64-75, 2011 (PubMed).

Devriendt, Verdonck, Summerfield, Goddeeris, Cox: "Targeting of Escherichia coli F4 fimbriae to Fcgamma receptors enhances the maturation of porcine dendritic cells." in: Veterinary immunology and immunopathology, Vol. 135, Issue 3-4, pp. 188-98, 2010 (PubMed).

Santer, Hall, George, Tangsombatvisit, Liu, Arkwright, Elkon: "C1q deficiency leads to the defective suppression of IFN-alpha in response to nucleoprotein containing immune complexes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 8, pp. 4738-49, 2010 (PubMed).

Dutertre, Bonnin-Gélizé, Pulford, Bourel, Fridman, Teillaud: "A novel subset of NK cells expressing high levels of inhibitory FcgammaRIIB modulating antibody-dependent function." in: Journal of leukocyte biology, Vol. 84, Issue 6, pp. 1511-20, 2008 (PubMed).

Khan, Kim, Kim: "Synthesis and control of physical properties of titania nanoparticles as a function of synthetic parameters." in: Journal of nanoscience and nanotechnology, Vol. 8, Issue 9, pp. 4738-42, 2008 (PubMed).

Benitez-Ribas, Adema, Winkels, Klasen, Punt, Figdor, de Vries: "Plasmacytoid dendritic cells of melanoma patients present exogenous proteins to CD4+ T cells after Fc gamma RII-mediated uptake." in: The Journal of experimental medicine, Vol. 203, Issue 7, pp. 1629-35, 2006 (PubMed).

Sims, Ettinger, Shirota, Yarboro, Illei, Lipsky: "Identification and characterization of circulating human transitional B cells." in: Blood, Vol. 105, Issue 11, pp. 4390-8, 2005 (PubMed).

Lilliehöök, Johannisson, Håkansson: "Expression of adhesion and Fcgamma-receptors on canine blood eosinophils and neutrophils studied by anti-human monoclonal antibodies." in: Veterinary immunology and immunopathology, Vol. 61, Issue 2-4, pp. 181-93, 1998 (PubMed).

Van Den Herik-Oudijk, Westerdaal, Henriquez, Capel, Van De Winkel: "Functional analysis of human Fc gamma RII (CD32) isoforms expressed in B lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 152, Issue 2, pp. 574-85, 1994 (PubMed).

Greenman, Tutt, George, Pulford, Stevenson, Glennie: "Characterization of a new monoclonal anti-Fc gamma RII antibody, AT10, and its incorporation into a bispecific F(ab')2 derivative for recruitment of cytotoxic effectors." in: Molecular immunology, Vol. 28, Issue 11, pp. 1243-54, 1992 (PubMed).