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E-cadherin antibody (Cadherin 1, Type 1, E-Cadherin (Epithelial))

Details for Product anti-CDH1 Antibody No. ABIN1106272, Supplier: Log in to see
Antigen
  • AA960649
  • arc-1
  • Arc-1
  • Arc1
  • b-cadherin
  • cadherin-1
  • CD324
  • cd324
  • cdh1
  • cdh1-a
  • cdhc-A
  • cdhe
  • CDHE
  • cdhp
  • E-Cad
  • E-cad
  • E-cadherin
  • ecad
  • Ecad
  • ECAD
  • hjmd
  • L-CAM
  • l-cam
  • lcam
  • LCAM
  • pcad
  • si:dz180o5.2
  • Um
  • uvo
  • UVO
  • uvomorulin
  • xb-cad
  • XB-cadherin
  • XBcad
  • xcdh1
  • XTCAD-1
Reactivity
Human, Monkey, Mouse (Murine)
625
161
96
24
22
12
6
6
4
3
3
3
1
1
1
1
1
1
1
1
1
1
Host
Mouse
377
264
27
18
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This E-cadherin antibody is un-conjugated
38
31
27
17
16
14
14
10
10
9
8
8
8
8
8
8
8
7
7
7
6
5
4
3
3
3
3
3
2
2
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
490
217
192
168
135
131
106
100
65
32
11
9
6
4
2
2
2
2
2
2
1
1
1
1
1
Supplier
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Clone 7H12
Isotype IgG1
Specificity Recognizes CDH1 (CD324 / Cadherin-1).
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse, Monkey.
Purification Ascites
Alternative Name CD324 / Cadherin-1 (CDH1 Antibody Abstract)
Background E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.Synonyms: CAM 120/80, CDH1, CDHE, E-cadherin, Epithelial cadherin, UVO, Uvomorulin
Molecular Weight 135 kDa
Gene ID 999
Research Area Extracellular Matrix, Signaling, Cytoskeleton
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Flow Cytometry (FACS) image for anti-E-cadherin antibody (Cadherin 1, Type 1, E-Cadherin (Epithelial)) (ABIN1106272) anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibody
Western Blotting (WB) image for anti-E-cadherin antibody (Cadherin 1, Type 1, E-Cadherin (Epithelial)) (ABIN1106272) anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-E-cadherin antibody (Cadherin 1, Type 1, E-Cadherin (Epithelial)) (ABIN1106272) anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibody (Image 3)
Background publications Schietke, Warnecke, Wacker, Schödel, Mole, Campean, Amann, Goppelt-Struebe, Behrens, Eckardt, Wiesener: "The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1." in: The Journal of biological chemistry, Vol. 285, Issue 9, pp. 6658-69, 2010 (PubMed).

Barrett, Lee, Lees, Prescott, Anderson, Phillips, Wesley, Parnell, Zhang, Drummond, Nimmo, Massey, Blaszczyk, Elliott, Cotterill, Dallal, Lobo, Mowat, Sanderson, Jewell, Newman, Edwards, Ahmad et al.: "Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. ..." in: Nature genetics, Vol. 41, Issue 12, pp. 1330-4, 2009 (PubMed).

Wang, Yao, Zhang, Zhang, Zhao: "[Expression and significance of CD147 and E-cadherin in human gastric carcinoma]." in: Zhonghua zhong liu za zhi [Chinese journal of oncology], Vol. 31, Issue 7, pp. 515-9, 2009 (PubMed).