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E-cadherin antibody (Cadherin 1, Type 1, E-Cadherin (Epithelial))

Details for Product anti-CDH1 Antibody No. ABIN1106273, Supplier: Log in to see
Antigen
  • E-Cad
  • E-cadherin
  • XB-cadherin
  • XBcad
  • XTCAD-1
  • b-cadherin
  • cadherin-1
  • cdh1-a
  • cdhc-A
  • cdhp
  • hjmd
  • l-cam
  • lcam
  • pcad
  • uvo
  • uvomorulin
  • xb-cad
  • xcdh1
  • Arc1
  • AA960649
  • E-cad
  • Ecad
  • L-CAM
  • UVO
  • Um
  • Arc-1
  • CD324
  • CDHE
  • ECAD
  • LCAM
  • arc-1
  • cd324
  • cdhe
  • ecad
  • cdh1
  • si:dz180o5.2
Reactivity
Human, Monkey, Mouse (Murine)
428
130
95
21
20
11
6
4
4
3
2
1
1
1
1
1
1
1
1
1
1
1
Host
Mouse
254
193
18
17
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This E-cadherin antibody is un-conjugated
29
24
18
13
10
7
6
5
4
4
3
3
3
3
3
3
2
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
309
143
100
95
93
58
48
43
36
32
12
9
6
4
2
2
2
2
2
1
1
1
1
1
Supplier
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Clone 7A2
Isotype IgG1
Specificity Recognizes CD324 / Cadherin-1
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse, Monkey.
Purification Ascites
Alternative Name CD324 / Cadherin-1 (CDH1 Antibody Abstract)
Background E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.Synonyms: CAM 120/80, CDH1, CDHE, E-cadherin, Epithelial cadherin, UVO, Uvomorulin
Molecular Weight 135 kDa
Gene ID 999
Research Area Extracellular Matrix, Signaling, Cytoskeleton
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Western Blotting (WB) image for anti-E-cadherin antibody (Cadherin 1, Type 1, E-Cadherin (Epithelial)) (ABIN1106273) anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibody
Background publications Schietke, Warnecke, Wacker et al.: "The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1." in: The Journal of biological chemistry, Vol. 285, Issue 9, pp. 6658-69, 2010 (PubMed).

Wang, Yao, Zhang et al.: "[Expression and significance of CD147 and E-cadherin in human gastric carcinoma]." in: Zhonghua zhong liu za zhi [Chinese journal of oncology], Vol. 31, Issue 7, pp. 515-9, 2009 (PubMed).

Barrett, Lee, Lees et al.: "Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. ..." in: Nature genetics, Vol. 41, Issue 12, pp. 1330-4, 2009 (PubMed).