E-cadherin antibody (Cadherin 1, Type 1, E-Cadherin (Epithelial))

Details for Product anti-CDH1 Antibody No. ABIN1106273, Supplier: Log in to see
Antigen
  • E-Cad
  • E-cadherin
  • XB-cadherin
  • XBcad
  • XTCAD-1
  • b-cadherin
  • cadherin-1
  • cdh1-a
  • cdhc-A
  • cdhp
  • hjmd
  • l-cam
  • lcam
  • pcad
  • uvo
  • uvomorulin
  • xb-cad
  • xcdh1
  • Arc1
  • AA960649
  • E-cad
  • Ecad
  • L-CAM
  • UVO
  • Um
  • Arc-1
  • CD324
  • CDHE
  • ECAD
  • LCAM
  • arc-1
  • cd324
  • cdhe
  • ecad
  • cdh1
  • si:dz180o5.2
  • cadherin 3, type 1, P-cadherin (placental)
  • Aerobic running capacity QTL 1
  • cadherin 1
  • cadherin 1, type 1, E-cadherin (epithelial)
  • E-cadherin-like
  • si:busm1-180o5.2
  • cdh3-a
  • Arunc1
  • Cdh1
  • CDH1
  • cdh1
  • LOC100356548
  • si:busm1-180o5.2
Alternatives
anti-Human E-cadherin antibody for Immunofluorescence (fixed cells)
Reactivity
Human, Monkey, Mouse (Murine)
762
235
146
39
26
16
9
8
8
6
5
4
3
1
1
1
1
1
1
1
1
1
Host
Mouse
508
264
35
22
1
Clonality (Clone)
Monoclonal ()
Conjugate
This E-cadherin antibody is un-conjugated
42
38
33
23
20
20
16
15
15
15
14
12
12
12
12
11
11
11
9
8
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4
3
3
3
3
3
3
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
597
346
270
197
166
159
153
89
81
38
14
14
13
9
7
6
6
4
2
2
2
2
2
2
1
1
1
1
Options
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Clone 7A2
Isotype IgG1
Specificity Recognizes CD324 / Cadherin-1
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse, Monkey.
Purification Ascites
Alternative Name CD324 / Cadherin-1 (CDH1 Antibody Abstract)
Background E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.Synonyms: CAM 120/80, CDH1, CDHE, E-cadherin, Epithelial cadherin, UVO, Uvomorulin
Molecular Weight 135 kDa
Gene ID 999
Research Area Extracellular Matrix, Signaling, Cytoskeleton
Pathways Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Western Blotting (WB) image for anti-E-cadherin antibody (Cadherin 1, Type 1, E-Cadherin (Epithelial)) (ABIN1106273) anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibody
Background publications Schietke, Warnecke, Wacker, Schödel, Mole, Campean, Amann, Goppelt-Struebe, Behrens, Eckardt, Wiesener: "The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1." in: The Journal of biological chemistry, Vol. 285, Issue 9, pp. 6658-69, 2010 (PubMed).

Barrett, Lee, Lees, Prescott, Anderson, Phillips, Wesley, Parnell, Zhang, Drummond, Nimmo, Massey, Blaszczyk, Elliott, Cotterill, Dallal, Lobo, Mowat, Sanderson, Jewell, Newman, Edwards, Ahmad et al.: "Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. ..." in: Nature genetics, Vol. 41, Issue 12, pp. 1330-4, 2009 (PubMed).

Wang, Yao, Zhang, Zhang, Zhao: "[Expression and significance of CD147 and E-cadherin in human gastric carcinoma]." in: Zhonghua zhong liu za zhi [Chinese journal of oncology], Vol. 31, Issue 7, pp. 515-9, 2009 (PubMed).