ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) (AA 221-394) antibody

Details for Product No. ABIN1106294
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Antigen
Synonyms bcrp, ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1, AI428558, Bcrp1, ABCG3
Epitope
AA 221-394
(5), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(102), (62), (41), (19), (11), (1), (1), (1), (1), (1), (1)
Host
Rat
(65), (38), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(73), (40), (24), (23), (21), (20), (15), (15), (15), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 1 mL
Shipping to United States (Change)
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Catalog No. ABIN1106294
588.50 $
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Immunogen Fusion protein containing the E. coli maltose binding protein and a fragment of the Mouse bcrp protein corresponding to amino acids 221-394.
Clone BXP-9
Isotype IgG1
Specificity This Monoclonal antibody clone BXP-9 reacts with an internal epitope of bcrp, a 70 kD transmembrane half-transporter which is involved in Multidrug resistance. It does not react with the Human BCRP molecule.
Purification Supernatant
Alternative Name CD338 / ABCG2 / BCRP1
Background The breast cancer resistance protein (BCRP/ABCG2) is a member of the ATP-binding cassette family of drug transporters and confers resistance to various anticancer drugs. The membrane-associated protein encoded by this gene is included in the superfamily of ATP- binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.
Alternate names: ABCP, ATP-binding cassette sub-family G member 2, Breast cancer resistance protein 1, MXR, Mitoxantrone resistance-associated protein, Placenta-specific ATP-binding cassette transporter
Gene ID 26357
NCBI Accession NP_036050
UniProt Q7TMS5
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg IgG/ml
Buffer 0.09% Sodium Azide 0.7% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Doyle, Yang, Abruzzo et al.: "A multidrug resistance transporter from human MCF-7 breast cancer cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 26, pp. 15665-70, 1999 (PubMed).

Scheffer, Maliepaard, Pijnenborg et al.: "Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines." in: Cancer research, Vol. 60, Issue 10, pp. 2589-93, 2000 (PubMed).

Jonker, Buitelaar, Wagenaar et al.: "The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 24, pp. 15649-54, 2002 (PubMed).

Eggers, Da Silva, Darwish et al.: "Self-assembled monolayers formed using zero net curvature norbornylogous bridges: the influence of potential on molecular orientation." in: Langmuir : the ACS journal of surfaces and colloids, Vol. 26, Issue 19, pp. 15665-70, 2010 (PubMed).

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