ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) antibody

Details for Product No. ABIN1106296
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Synonyms bcrp, ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1, AI428558, Bcrp1, ABCG3
(104), (37), (11), (9), (2), (1), (1), (1), (1), (1), (1), (1)
(59), (47), (10)
Clonality (Clone)
Monoclonal ()
(5), (3), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
(95), (39), (38), (29), (22), (15), (11), (9), (9), (4), (3), (2), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 1 mL
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Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN1106296
533.50 $
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Immunogen Immunization with the mitoxanthrone resistant, BCRP overexpressing cell line MCF7 MR.
Clone BXP-34
Isotype IgG1
Specificity This Monoclonal antibody BXP-34 reacts with an internal epitope of BCRP, a 70 kDa transmembrane half-transporter which is involved in multidrug resistance. It did not cross-react with the Human MDR1, MRP1, MRP2, MRP5 gene products.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Alternative Name CD338 / ABCG2 / BCRP1
Background The breast cancer resistance protein (BCRP/ABCG2) is a member of the ATP-binding cassette family of drug transporters and confers resistance to various anticancer drugs. The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.Synonyms: ABCP, ATP-binding cassette sub-family G member 2, Breast cancer resistance protein 1, MXR, Mitoxantrone resistance-associated protein, Placenta-specific ATP-binding cassette transporter
Gene ID 9429
NCBI Accession NP_004818
UniProt Q9UNQ0
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg IgG/ml
Buffer 0.09 % Sodium Azide 9 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Eggers, Da Silva, Darwish et al.: "Self-assembled monolayers formed using zero net curvature norbornylogous bridges: the influence of potential on molecular orientation." in: Langmuir : the ACS journal of surfaces and colloids, Vol. 26, Issue 19, pp. 15665-70, 2010 (PubMed).

van der Kolk, Vellenga, Scheffer et al.: "Expression and activity of breast cancer resistance protein (BCRP) in de novo and relapsed acute myeloid leukemia." in: Blood, Vol. 99, Issue 10, pp. 3763-70, 2002 (PubMed).

Scheffer, Maliepaard, Pijnenborg et al.: "Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines." in: Cancer research, Vol. 60, Issue 10, pp. 2589-93, 2000 (PubMed).

Doyle, Yang, Abruzzo et al.: "A multidrug resistance transporter from human MCF-7 breast cancer cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 26, pp. 15665-70, 1999 (PubMed).

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