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CD45 antibody

PTPRC Reactivity: Human FACS, IF, IHC (p), IHC (fro) Host: Mouse Monoclonal MT2 unconjugated
Catalog No. ABIN1106411
  • Target See all CD45 (PTPRC) Antibodies
    CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))
    Reactivity
    • 394
    • 227
    • 79
    • 29
    • 20
    • 16
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    • 10
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    Human
    Host
    • 282
    • 178
    • 148
    • 2
    • 1
    • 1
    Mouse
    Clonality
    • 467
    • 137
    • 1
    Monoclonal
    Conjugate
    • 175
    • 60
    • 51
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    • 39
    • 15
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    • 1
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    This CD45 antibody is un-conjugated
    Application
    • 503
    • 207
    • 152
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    • 74
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    • 47
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    Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    Clone MT2, specific for CD45RC, reacts with with a 95-115 kDa highly sialated glycoprotein. Clone MT2 has previously been described as CD45RA but due to its reactivity with transfectants and its identical staining pattern with ORTH75E4 it is now recognized as CD45RC [7]. Clone MT2 reacts with peripheral blood B cells and is used for the differential diagnosis of non-Hodgkin lymphomas. It also reacts with T suppressor/cytotoxic cells and NK cells. Other isoforms can be detected using anti-CD45RA (clone MB1, cat.no. AM39020), or anti-CD45RB (clone MT4, cat.no. AM39021).
    Purification
    Affinity chromatography
    Clone
    MT2
    Isotype
    IgG1
    Top Product
    Discover our top product PTPRC Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    0.01 M Sodium Phosphate, 0.15 M NaCl, pH 7.3, 0.09 % Sodium Azide, 0.2 % BSA
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.
  • Target
    CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))
    Alternative Name
    CD45 / LCA (PTPRC Products)
    Synonyms
    PTPRC antibody, si:dkeyp-47c5.1 antibody, B220 antibody, CD45 antibody, CD45R antibody, GP180 antibody, L-CA antibody, LCA antibody, LY5 antibody, T200 antibody, Cd45 antibody, Ly-5 antibody, Lyt-4 antibody, loc antibody, Lca antibody, RT7 antibody, cd45 antibody, protein tyrosine phosphatase, receptor type C antibody, protein tyrosine phosphatase, receptor type, C antibody, receptor-type tyrosine-protein phosphatase C antibody, PTPRC antibody, ptprc antibody, LOC100074271 antibody, Ptprc antibody
    Background
    The CD45 Molecule is also known as the Leukocyte Common Antigen (LCA) or T200 antigen, and is comprised of different glycoproteins ranging from 180-240 kD [1,2]. CD45 is a family of transmembrane protein tyrosine phosphatases critically involved in the regulation of lymphocyte activation signals. Expression of CD45 is found on all hemopoietic cells, e.g. granulocytes, monocytes, macrophages and lymphocytes, except mature erythroid cells. In humans, there is heterogeneous expression of CD45 isoforms (RA, RB, RO, RC) on lymphocyte subpopulations. Detection of the different isoforms can distinguish, for example, between naive T cells and memory T cells, which is of interest in patients with immunodeficiency and autoimmune diseases.Synonyms: L-CA, Leukocyte common antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C, T200
    Gene ID
    5788
    NCBI Accession
    NP_002829
    UniProt
    P08575
    Pathways
    TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, BCR Signaling
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