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CD45 antibody (Protein tyrosine Phosphatase, Receptor Type, C)

Details for Product anti-PTPRC Antibody No. ABIN1106411, Supplier: Log in to see
Antigen
  • PTPRC
  • si:dkeyp-47c5.1
  • B220
  • CD45
  • CD45R
  • GP180
  • L-CA
  • LCA
  • LY5
  • T200
  • Cd45
  • Ly-5
  • Lyt-4
  • loc
  • Lca
  • RT7
  • cd45
  • protein tyrosine phosphatase, receptor type, C
  • PTPRC
  • ptprc
  • Ptprc
Alternatives
anti-Human CD45 antibody for Immunocytochemistry
Reactivity
Human
1347
706
184
127
64
45
44
43
22
19
19
12
5
5
4
3
2
1
1
1
1
1
1
Host
Mouse
1373
733
230
3
2
Clonality (Clone)
Monoclonal ()
Conjugate
This CD45 antibody is un-conjugated
251
219
167
91
63
62
61
54
48
41
36
34
33
33
33
29
27
26
26
21
19
17
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14
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11
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5
5
5
5
5
4
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
1924
531
522
519
461
432
407
358
202
54
38
30
28
16
11
10
7
6
6
6
4
4
3
2
2
2
2
2
2
2
1
1
1
Options
Supplier
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Clone MT2
Isotype IgG1
Specificity Clone MT2, specific for CD45RC, reacts with with a 95-115 kDa highly sialated glycoprotein. Clone MT2 has previously been described as CD45RA but due to its reactivity with transfectants and its identical staining pattern with ORTH75E4 it is now recognized as CD45RC [7]. Clone MT2 reacts with peripheral blood B cells and is used for the differential diagnosis of non-Hodgkin lymphomas. It also reacts with T suppressor/cytotoxic cells and NK cells. Other isoforms can be detected using anti-CD45RA (clone MB1, cat.no. AM39020), or anti-CD45RB (clone MT4, cat.no. AM39021).
Purification Affinity chromatography
Alternative Name CD45 / LCA (PTPRC Antibody Abstract)
Background The CD45 Molecule is also known as the Leukocyte Common Antigen (LCA) or T200 antigen, and is comprised of different glycoproteins ranging from 180-240 kD [1,2]. CD45 is a family of transmembrane protein tyrosine phosphatases critically involved in the regulation of lymphocyte activation signals. Expression of CD45 is found on all hemopoietic cells, e.g. granulocytes, monocytes, macrophages and lymphocytes, except mature erythroid cells. In humans, there is heterogeneous expression of CD45 isoforms (RA, RB, RO, RC) on lymphocyte subpopulations. Detection of the different isoforms can distinguish, for example, between naive T cells and memory T cells, which is of interest in patients with immunodeficiency and autoimmune diseases.Synonyms: L-CA, Leukocyte common antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C, T200
Gene ID 5788
NCBI Accession NP_002829
UniProt P08575
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer 0.01 M Sodium Phosphate, 0.15 M NaCl, pH 7.3, 0.09 % Sodium Azide, 0.2 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.
Supplier Images
 image for anti-CD45 antibody (Protein tyrosine Phosphatase, Receptor Type, C) (ABIN1106411) anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) antibody
Background publications Young, Ramage, Gaston, Beverley: "In vitro responses of human CD45R0brightRA- and CD45R0-RAbright T cell subsets and their relationship to memory and naive T cells." in: European journal of immunology, Vol. 27, Issue 9, pp. 2383-90, 1997 (PubMed).

Thomas: "The leukocyte common antigen family." in: Annual review of immunology, Vol. 7, pp. 339-69, 1989 (PubMed).

Streuli, Hall, Saga, Schlossman, Saito: "Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens." in: The Journal of experimental medicine, Vol. 166, Issue 5, pp. 1548-66, 1987 (PubMed).

Hall, DArdenne, Butler, Habeshaw, Stansfeld: "New marker of B lymphocytes, MB2: comparison with other lymphocyte subset markers active in conventionally processed tissue sections." in: Journal of clinical pathology, Vol. 40, Issue 2, pp. 151-6, 1987 (PubMed).

Poppema, Hollema, Visser, Vos: "Monoclonal antibodies (MT1, MT2, MB1, MB2, MB3) reactive with leukocyte subsets in paraffin-embedded tissue sections." in: The American journal of pathology, Vol. 127, Issue 3, pp. 418-29, 1987 (PubMed).

West, Warford, Fray, Allen, Campbell, Lauder: "The demonstration of B-cell, T-cell and myeloid antigens in paraffin sections." in: The Journal of pathology, Vol. 150, Issue 2, pp. 89-101, 1987 (PubMed).