CD48 antibody (CD48 Molecule) (APC)

Details for Product anti-CD48 Antibody No. ABIN1106423, Supplier: Log in to see
Antigen
  • AI449234
  • AW610730
  • BCM1
  • BLAST
  • BLAST-1
  • BLAST1
  • Bcm-1
  • MEM-102
  • SLAMF2
  • Sgp-60
  • hCD48
  • mCD48
  • CD48 antigen
  • Cd48 molecule
  • CD48 molecule
  • Cd48
  • CD48
Reactivity
Human, Monkey
196
127
33
16
9
5
5
2
1
1
1
1
Host
Mouse
172
60
57
42
4
4
Clonality (Clone)
Monoclonal ()
Conjugate
This CD48 antibody is conjugated to APC
42
42
18
16
8
8
7
6
4
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Application
Flow Cytometry (FACS)
263
88
47
34
31
26
23
11
9
5
4
4
3
3
3
2
2
2
1
1
1
Options
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Clone MEM-102
Isotype IgG1
Specificity This antibody recognises the CD48 antigen which is widely distributed on leucocytes with a distinctive reaction pattern. The antigen is structurally closely related to the B-cell activation antigen Blast-1.
Purification Purified IgG prepared by ion exchange chromatography.
Alternative Name CD48 (CD48 Antibody Abstract)
Background CD48 is a glycosyl phophatidyl inositol (GPI) anchored cell surface protein also known as Blast1, HuLy m3, BCM1 (in mouse), and OX45 (in rat). CD48 is strongly expressed on lymphocytes and monocytes and weakly on granulocytes but is absent on platelets, fibrolasts, epithelium and endothelium. CD48 is one of the markers for detecting the defects of GPI anchoring structure on patients with paroxysmal nocturnal hemoglobulinuria (PNH) and serves as a low affinity ligand for CD2. The CD48 antigen is closely related to the activation antigen, Blast 1.Synonyms: B-lymphocyte activation marker BLAST-1, BCM1, BCM1 surface antigen, BLAST1, Leukocyte antigen MEM-102, MEM-102, TCT.1
Gene ID 962
NCBI Accession NP_001769
UniProt P09326
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Reconstitution Reconstitute with 1 mL distilled water.
Concentration 0.1 mg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Prior to and following reconstitution store the antibody at 2-8 °C.
Background publications Staffler, Szekeres, Schütz, Säemann, Prager, Zeyda, Drbal, Zlabinger, Stulnig, Stockinger: "Selective inhibition of T cell activation via CD147 through novel modulation of lipid rafts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 4, pp. 1707-14, 2003 (PubMed).

Cinek, Horejsí: "The nature of large noncovalent complexes containing glycosyl-phosphatidylinositol-anchored membrane glycoproteins and protein tyrosine kinases." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 7, pp. 2262-70, 1992 (PubMed).

Korínek, Stefanová, Angelisová, Hilgert, Horejsí: "The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1." in: Immunogenetics, Vol. 33, Issue 2, pp. 108-12, 1991 (PubMed).

Horejsí, Angelisová, Bazil, Kristofová, Stoyanov, Stefanová, Hausner, Vosecký, Hilgert et al.: "Monoclonal antibodies against human leucocyte antigens. II. Antibodies against CD45 (T200), CD3 (T3), CD43, CD10 (CALLA), transferrin receptor (T9), a novel broadly expressed 18-kDa antigen (MEM-43) ..." in: Folia biologica, Vol. 34, Issue 1, pp. 23-34, 1988 (PubMed).