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Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A) antibody (FITC)

Details for Product No. ABIN1106520, Supplier: Log in to see
Antigen
  • AI323638
  • AV092959
  • CD64
  • CD64A
  • FcgammaRI
  • Fcgr1
  • FCGR1A
  • Fcgr1b
  • FCRI
  • IGFR1
  • IGGHAFC
Reactivity
Human
272
39
19
18
17
8
7
7
6
Host
Mouse
233
52
7
Clonality (Clone)
Monoclonal ()
Conjugate
FITC
37
34
18
11
8
6
5
5
4
4
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF)
211
113
49
41
39
33
31
30
25
15
11
8
7
4
2
2
2
1
Supplier
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Clone 32-2
Isotype IgG1
Specificity This antibody binds to a CD64 epitope distinct from the ligand-binding site and from the clone 22 antibody (cat.no. AM39025) to CD64 epitope. It shows especially high affinity binding to human mononuclear phagocytes and polymorphonuclear leukocytes exposed to IFN-γ or G-CSF. Its binding is not blocked in the presence of human IgG or immune complexes.
Alternative Name CD64 / FCGR1A (FCGR1A Antibody Abstract)
Background CD64 reacts with the Fc gamma receptor 1 (FcγR1), a glycoprotein with a molecular weight of 72 kDa. The antigen is a high-affinity receptor for IgG and is able to bind human IgG1 and IgG3. The antigen is expressed on macrophages, monocytes, and interferon γ (IFN-γ) and Granulocyte Colony Stimulating Factor (G-CSF) stimulated neutrophils.Synonyms: Fc-gamma RI, Fc-gamma RIA, FcRI, FcgammaRIa, High affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I
Gene ID 2209
NCBI Accession NP_000557
UniProt P12314
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer 0.01 M Sodium Phosphate, 0.11 M NaCl, pH 7.3, 0.09 % Sodium Azide, 0.2 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.
Background publications Davis, Bigelow: "Comparison of neutrophil CD64 expression, manual myeloid immaturity counts, and automated hematology analyzer flags as indicators of infection or sepsis." in: Laboratory hematology : official publication of the International Society for Laboratory Hematology, Vol. 11, Issue 2, pp. 137-47, 2005 (PubMed).

Schiff, Rae, Martin, Davis, Curnutte: "Increased phagocyte Fc gammaRI expression and improved Fc gamma-receptor-mediated phagocytosis after in vivo recombinant human interferon-gamma treatment of normal human subjects." in: Blood, Vol. 90, Issue 8, pp. 3187-94, 1997 (PubMed).

Leino, Sorvajärvi, Katajisto, Laine, Lilius, Pelliniemi, Rajamäki, Silvoniemi, Nikoskelainen: "Febrile infection changes the expression of IgG Fc receptors and complement receptors in human neutrophils in vivo." in: Clinical and experimental immunology, Vol. 107, Issue 1, pp. 37-43, 1997 (PubMed).

Pizza, Davis, Henrickson, Mitchell, Pace, Bigelow, DiLauro, Naglieri: "Adaptation to eccentric exercise: effect on CD64 and CD11b/CD18 expression." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 80, Issue 1, pp. 47-55, 1996 (PubMed).

Akerley, Guyre, Davis: "Neutrophil activation through high-affinity Fc gamma receptor using a monomeric antibody with unique properties." in: Blood, Vol. 77, Issue 3, pp. 607-15, 1991 (PubMed).

Guyre, Campbell, Kniffin, Fanger: "Monocytes and polymorphonuclear neutrophils of patients with streptococcal pharyngitis express increased numbers of type I IgG Fc receptors." in: The Journal of clinical investigation, Vol. 86, Issue 6, pp. 1892-6, 1991 (PubMed).

Pan, Mendel, Zurlo, Guyre: "Regulation of the steady state level of Fc gamma RI mRNA by IFN-gamma and dexamethasone in human monocytes, neutrophils, and U-937 cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 145, Issue 1, pp. 267-75, 1990 (PubMed).

Petroni, Shen, Guyre: "Modulation of human polymorphonuclear leukocyte IgG Fc receptors and Fc receptor-mediated functions by IFN-gamma and glucocorticoids." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 140, Issue 10, pp. 3467-72, 1988 (PubMed).