Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A) antibody (PE)

Details for Product No. ABIN1106522, Supplier: Log in to see
Antigen
  • CD64
  • CD64A
  • FCRI
  • IGFR1
  • FcgammaRI
  • Fcgr1
  • Fcgr1b
  • AI323638
  • AV092959
  • IGGHAFC
  • FCGR1A
  • Fc fragment of IgG, high affinity Ia, receptor (CD64)
  • Fc receptor, IgG, high affinity I
  • high affinity immunoglobulin gamma Fc receptor I
  • FCGR1A
  • Fcgr1a
  • Fcgr1
  • FCGR1
Alternatives
anti-Human Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) antibody for Blocking Reagent
Reactivity
Human
302
41
25
19
13
12
12
6
6
1
Host
Mouse
261
54
7
Clonality (Clone)
Monoclonal ()
Conjugate
PE
39
35
18
11
10
10
8
7
6
6
6
6
4
4
4
4
3
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF)
237
120
62
43
42
31
30
30
24
13
10
10
10
7
4
3
2
2
2
2
2
1
Options
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Clone 32-2
Isotype IgG1
Specificity This antibody binds to a CD64 epitope distinct from the ligand-binding site and from the clone 22 antibody (cat.no. AM39025) to CD64 epitope. It shows especially high affinity binding to human mononuclear phagocytes and polymorphonuclear leukocytes exposed to IFN-γ or G-CSF. Its binding is not blocked in the presence of human IgG or immune complexes.
Alternative Name CD64 / FCGR1A (FCGR1A Antibody Abstract)
Background CD64 reacts with the Fc gamma receptor 1 (FcγR1), a glycoprotein with a molecular weight of 72 kDa. The antigen is a high-affinity receptor for IgG and is able to bind human IgG1 and IgG3. The antigen is expressed on macrophages, monocytes, and interferon γ (IFN-γ) and Granulocyte Colony Stimulating Factor (G-CSF) stimulated neutrophils.Synonyms: Fc-gamma RI, Fc-gamma RIA, FcRI, FcgammaRIa, High affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I
Gene ID 2209
NCBI Accession NP_000557
UniProt P12314
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer 0.01 M Sodium Phosphate, 0.11 M NaCl, pH 7.3, 0.09 % Sodium Azide, 0.2 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.
Background publications Davis, Bigelow: "Comparison of neutrophil CD64 expression, manual myeloid immaturity counts, and automated hematology analyzer flags as indicators of infection or sepsis." in: Laboratory hematology : official publication of the International Society for Laboratory Hematology, Vol. 11, Issue 2, pp. 137-47, 2005 (PubMed).

Schiff, Rae, Martin, Davis, Curnutte: "Increased phagocyte Fc gammaRI expression and improved Fc gamma-receptor-mediated phagocytosis after in vivo recombinant human interferon-gamma treatment of normal human subjects." in: Blood, Vol. 90, Issue 8, pp. 3187-94, 1997 (PubMed).

Leino, Sorvajärvi, Katajisto, Laine, Lilius, Pelliniemi, Rajamäki, Silvoniemi, Nikoskelainen: "Febrile infection changes the expression of IgG Fc receptors and complement receptors in human neutrophils in vivo." in: Clinical and experimental immunology, Vol. 107, Issue 1, pp. 37-43, 1997 (PubMed).

Pizza, Davis, Henrickson, Mitchell, Pace, Bigelow, DiLauro, Naglieri: "Adaptation to eccentric exercise: effect on CD64 and CD11b/CD18 expression." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 80, Issue 1, pp. 47-55, 1996 (PubMed).

Akerley, Guyre, Davis: "Neutrophil activation through high-affinity Fc gamma receptor using a monomeric antibody with unique properties." in: Blood, Vol. 77, Issue 3, pp. 607-15, 1991 (PubMed).

Guyre, Campbell, Kniffin, Fanger: "Monocytes and polymorphonuclear neutrophils of patients with streptococcal pharyngitis express increased numbers of type I IgG Fc receptors." in: The Journal of clinical investigation, Vol. 86, Issue 6, pp. 1892-6, 1991 (PubMed).

Pan, Mendel, Zurlo, Guyre: "Regulation of the steady state level of Fc gamma RI mRNA by IFN-gamma and dexamethasone in human monocytes, neutrophils, and U-937 cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 145, Issue 1, pp. 267-75, 1990 (PubMed).

Petroni, Shen, Guyre: "Modulation of human polymorphonuclear leukocyte IgG Fc receptors and Fc receptor-mediated functions by IFN-gamma and glucocorticoids." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 140, Issue 10, pp. 3467-72, 1988 (PubMed).