CD80 antibody (CD80)

Details for Product anti-CD80 Antibody No. ABIN1106582, Supplier: Log in to see
Antigen
  • CD8
  • Leu2
  • MAL
  • p32
  • B71
  • Cd28l
  • Ly-53
  • Ly53
  • MIC17
  • TSA1
  • B7
  • B7-1
  • B7.1
  • BB1
  • CD28LG
  • CD28LG1
  • LAB7
  • CD80 molecule
  • CD8a molecule
  • CD80 antigen
  • Cd80 molecule
  • CD80
  • CD8A
  • Cd80
Alternatives
anti-Human CD80 antibody for Immunoprecipitation
Reactivity
Human
447
282
47
11
10
7
6
3
2
2
1
1
Host
Mouse
403
115
102
91
41
19
Clonality (Clone)
Monoclonal ()
Conjugate
This CD80 antibody is un-conjugated
76
74
53
26
20
18
15
14
13
12
10
10
8
8
8
8
7
7
7
5
5
4
4
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
526
205
140
137
122
80
64
44
31
30
26
17
9
8
7
6
5
5
5
4
2
2
2
2
1
1
1
Options
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Supplier Product No.
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Clone 2A2
Isotype IgG1
Specificity Recognizes CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name CD80 (CD80 Antibody Abstract)
Background The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.1. Its principal mode of action is by binding to CD28. Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells. CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells. Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells. Mouse research by scientists at Emory University showed that estrogen-related bone loss is linked to recently discovered pathways involving various proteins, such as CD80 and other functions. In a nutshell, reactive oxygen stimulates dendritic cells, which activate other immune cells to up-regulate production of CD80, the molecule co-responsible for T cell activation. "When this pathway is activated, it leads to increased T cell TNF production and ultimately to bone loss." In turn, T cells produce a protein, Tumor Necrosis Factor, which increases the formation of osteoclasts in rodents and humans. Osteoclasts cause minerals to be released from the bone, so that calcium is taken into the bloodstream to be used for other functions of the body. Osteoclast differentiation is inhibited by osteoprotegerin, Estrogen stimulates osteoprotegerin production.Synonyms: Activation B7-1 antigen, B7-1, B7.1, BB1, CD28LG, CD28LG1, CTLA-4 counter-receptor B7.1, LAB7, T-lymphocyte activation antigen CD80
Molecular Weight 55 kDa
Gene ID 941
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Immunohistochemistry (IHC) image for anti-CD80 (CD80) antibody (ABIN1106582) anti-CD80 (CD80) antibody
Immunofluorescence (IF) image for anti-CD80 (CD80) antibody (ABIN1106582) anti-CD80 (CD80) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-CD80 (CD80) antibody (ABIN1106582) anti-CD80 (CD80) antibody (Image 3)
Background publications Wang, Liu, Wu, Zhu, Wang, Xu: "Evaluation of CD86/CD28 and CD40/CD154 pathways in regulating monocyte-derived CD80 expression during their interaction with allogeneic endothelium." in: Transplantation proceedings, Vol. 40, Issue 8, pp. 2729-33, 2008 (PubMed).

Stephan, Ponomarev, Brentjens, Chang, Dobrenkov, Heller, Sadelain: "T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection." in: Nature medicine, Vol. 13, Issue 12, pp. 1440-9, 2007 (PubMed).