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CHEK1 antibody (Checkpoint Kinase 1)

Details for Product anti-CHEK1 Antibody No. ABIN1106682, Supplier: Log in to see
Antigen
  • An08g10320
  • AO090003000441
  • C85740
  • CHEK1
  • chk1
  • Chk1
  • CHK1
  • id:ibd2720
  • rad27
  • zgc:56093
Alternatives
anti-Human CHEK1 antibody for Immunoprecipitation
Reactivity
Human, Mouse (Murine)
451
149
140
5
4
4
3
2
2
2
1
1
Host
Mouse
394
50
22
6
Clonality (Clone)
Monoclonal ()
Conjugate
This CHEK1 antibody is un-conjugated
13
12
11
8
8
8
3
3
3
3
3
3
3
3
3
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
374
180
138
64
60
34
25
22
20
7
6
5
1
1
Supplier
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Clone 2G1D5
Isotype IgG1
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse.
Purification Purified
Alternative Name CHK1 (CHEK1 Antibody Abstract)
Background CHK1, also known as CHEK1, it is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by chk1 becomes bound by an adaptor protein in the cytoplasm. Therefore it is inhibited from removing the inhibiting phosphate from MPF (mitotic/maturation promoting factor) added by Wee1. Consequently, a cell is prevented from entering mitosis. Chk1 can also phosphorylate p53 at Ser20 in vitro.Synonyms: CHEK-1, CHEK1, CHK1 checkpoint homolog, Serine/threonine-protein kinase Chk1
Molecular Weight 56 kDa
Gene ID 1111
Research Area Kinases/Phosphatases, Cell Cycle
Pathways p53 Signaling, Apoptosis, Cell Division Cycle
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS, 0.03 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-CHEK1 antibody (Checkpoint Kinase 1) (ABIN1106682) anti-Checkpoint Kinase 1 (CHEK1) antibody
Western Blotting (WB) image for anti-CHEK1 antibody (Checkpoint Kinase 1) (ABIN1106682) anti-Checkpoint Kinase 1 (CHEK1) antibody (Image 2)
Background publications Matsuoka, Huang, Elledge: "Linkage of ATM to cell cycle regulation by the Chk2 protein kinase." in: Science (New York, N.Y.), Vol. 282, Issue 5395, pp. 1893-7, 1998 (PubMed).