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CRTC2 antibody (CREB Regulated Transcription Coactivator 2)

Details for Product anti-CRTC2 Antibody No. ABIN1106840, Supplier: Login to see
Antigen
  • CRTC2
  • TORC-2
  • TORC2
  • 4632407F12Rik
  • Torc2
  • mTORC2
  • RGD1308903
Alternatives
anti-Human CRTC2 antibody for Immunohistochemistry
Reactivity
Human, Monkey
127
53
37
7
7
7
4
2
2
2
Host
Mouse
80
55
14
2
Clonality (Clone)
Monoclonal ()
Conjugate
This CRTC2 antibody is un-conjugated
10
10
10
9
9
9
2
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
133
100
29
16
13
12
6
4
3
3
Supplier
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Clone 5B10
Isotype IgG1
Specificity Recognizes CRTC2 / TORC2
Cross-Reactivity (Details) Species reactivity (tested):Human, Monkey.
Purification Ascites
Alternative Name CRTC2 / TORC2 (CRTC2 Antibody Abstract)
Background The protein Torc2 (transducer of regulated CREB activity 2) functions as a CREB co-activator and is implicated in mediating the effects of these two pathways . In quiescent cells, Torc2 is phosphorylated at Ser171 and becomes sequestered in the cytoplasm via an interaction with 14-3-3 proteins. Glucose and gut hormones lead to the dephosphorylation of Torc2 and its dissociation from 14-3-3 proteins. Dephosphorylated Torc2 enters the nucleus to promote CREB-dependent transcription. Torc2 plays a key role in the regulation of hepatic gluconeogenic gene transcription in response to hormonal and energy signals during fasting. Tissue specificity: Most abundantly expressed in the thymus. Present in both B and T lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas .Synonyms: CREB-regulated transcription coactivator 2, TORC-2, Transducer of CREB protein 2, Transducer of regulated cAMP response element-binding protein 2
Molecular Weight 80 kDa
Gene ID 200186
Pathways AMPK Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Immunofluorescence (IF) image for anti-CRTC2 antibody (CREB Regulated Transcription Coactivator 2) (ABIN1106840) anti-CREB Regulated Transcription Coactivator 2 (CRTC2) antibody
Immunohistochemistry (IHC) image for anti-CRTC2 antibody (CREB Regulated Transcription Coactivator 2) (ABIN1106840) anti-CREB Regulated Transcription Coactivator 2 (CRTC2) antibody (Image 2)
Western Blotting (WB) image for anti-CRTC2 antibody (CREB Regulated Transcription Coactivator 2) (ABIN1106840) anti-CREB Regulated Transcription Coactivator 2 (CRTC2) antibody (Image 3)
Flow Cytometry (FACS) image for anti-CRTC2 antibody (CREB Regulated Transcription Coactivator 2) (ABIN1106840) anti-CREB Regulated Transcription Coactivator 2 (CRTC2) antibody (Image 4)
Background publications Peng, Xie, Lu et al.: "Synthesis, photoelectric properties and photocatalytic activity of the Fe2O3/TiO2 heterogeneous photocatalysts." in: Physical chemistry chemical physics : PCCP, Vol. 12, Issue 28, pp. 8033-41, 2010 (PubMed).

Dentin, Liu, Koo et al.: "Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2." in: Nature, Vol. 449, Issue 7160, pp. 366-9, 2007 (PubMed).