Cyclin D2 antibody

Catalog No. ABIN1106875

Product Details anti-Cyclin D2 Antibody

Target: Cyclin D2 (CCND2)

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cyclin D2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificity: This antibody reacts to Cyclin D2.

Purification: Affinity chromatography

Immunogen: Recombinant human cyclin D2 protein

Clone: CY-D2

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 1.2 % sodium acetate or neutral PBS

Concentration: 0,1 mg/mL

Buffer: 1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Cyclin D2

Target: Cyclin D2 (CCND2)

Alternative Name: Cyclin D2 (CCND2 Products)

Synonyms: si:ch211-240j22.2 antibody, ccnd2 antibody, CCND2 antibody, kiak0002 antibody, zgc:162280 antibody, LOC100224096 antibody, KIAK0002 antibody, BF642806 antibody, C86853 antibody, Vin-1 antibody, Vin1 antibody, cD2 antibody, 2600016F06Rik antibody, AI256817 antibody, cyclin D2, b antibody, cyclin D2 S homeolog antibody, cyclin D2 antibody, G1/S-specific cyclin-D2 antibody, cyclin D2, a antibody, cyclin D2 L homeolog antibody, ccnd2b antibody, ccnd2.S antibody, CCND2 antibody, ccnd2 antibody, ccnd2a antibody, Ccnd2 antibody, ccnd2.L antibody

Background: Cyclin D2, also known as CCND2, is a human gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin D1, Cyclin D2 and Cyclin D3 are the members of the cyclin family. Cyclin D2 mapped to 12p131, since the CCND1 gene is on 11q13, this may be another bit of evidence of the homology of chromosomes 11 and 12. Choi D et al proved the expression of pseudogene cyclin D2 mRNA in the human ovary increases with age, which may be a novel marker for decreased ovarian function associated with the aging process.2 And knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Inaba et al. (1992) used murine cDNA clones for 3 cyclin D genes that are normally expressed during the G1 phase of the cell cycle to clone the cognate human genes. D-type cyclins (cyclins D1, D2, and D3) are regarded as essential links between cell environment and the core cell cycle machinery. Cyclin D2(CCND2) gene ia assigned to 12p13.Synonyms: CCND2, Cyclin-D2

Gene ID: 894

NCBI Accession: NP_001750

UniProt: P30279

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases