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Basic Cytokeratin antibody

Details for Product No. ABIN1106894, Supplier: Log in to see
Antigen
Reactivity
Chicken, Cow (Bovine), Human, Mouse (Murine), Rabbit, Rat (Rattus)
16
15
6
6
4
4
4
3
3
1
1
Host
Mouse
16
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
11
11
9
8
6
5
2
1
1
Supplier
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Clone AE3
Isotype IgG1
Cross-Reactivity (Details) Species reactivity (tested):Human, Rabbit, Mouse, Rat, Bovine and Chicken.
Purification Purified
Background Cytokeratins are intermediate filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue There are two types of Cytokeratins: the low weight, acidic type I cytokeratins and the high weight, basic or neutral type II. Cytokeratins are usually found in pairs comprising a type I Cytokeratin and a type II cytokeratin. The high molecular weight cytokeratins, which are the basic or neutral cytokeratins, comprise subtypes CK1 (67), CK2 (65.5), CK3 (64), CK4 (59), CK5 (58), CK6 (56), CK7 (54), CK8 (52.5) and CK9. The low molecular weight cytokeratins, which are the acidic cytokeratins, comprise subtypes CK10 (56.5), CK12 (56), CK13 (53), CK14 (50), CK16( 48), CK17 (46), CK18 (45), CK19(48) and CK20(46).
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Background publications Collin, Moll, Kubicka, Ouhayoun, Franke: "Characterization of human cytokeratin 2, an epidermal cytoskeletal protein synthesized late during differentiation." in: Experimental cell research, Vol. 202, Issue 1, pp. 132-41, 1992

Huvos, Woodard, Heilweil: "Postradiation malignant fibrous histiocytoma of bone. A clinicopathologic study of 20 patients." in: The American journal of surgical pathology, Vol. 10, Issue 1, pp. 9-18, 1986

Sun, Tseng, Huang, Cooper, Schermer, Lynch, Weiss, Eichner: "Monoclonal antibody studies of mammalian epithelial keratins: a review." in: Annals of the New York Academy of Sciences, Vol. 455, pp. 307-29, 1986

Spagnolo, Michie, Crabtree, Warnke, Rouse: "Monoclonal anti-keratin (AE1) reactivity in routinely processed tissue from 166 human neoplasms." in: American journal of clinical pathology, Vol. 84, Issue 6, pp. 697-704, 1986

Battifora, Sheibani, Tubbs, Kopinski, Sun: "Antikeratin antibodies in tumor diagnosis. Distinction between seminoma and embryonal carcinoma." in: Cancer, Vol. 54, Issue 5, pp. 843-8, 1984

Shi, Goodman, Bhan, Pilch, Chen, Sun: "Immunohistochemical study of nasopharyngeal carcinoma using monoclonal keratin antibodies." in: The American journal of pathology, Vol. 117, Issue 1, pp. 53-63, 1984

Woodcock-Mitchell, Eichner, Nelson, Sun: "Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies." in: The Journal of cell biology, Vol. 95, Issue 2 Pt 1, pp. 580-8, 1983

Herbert, Uhler: "Biosynthesis of polyprotein precursors to regulatory peptides." in: Cell, Vol. 30, Issue 1, pp. 1-2, 1982