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Keratin 13 (KRT13) antibody

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Synonyms krt13, CK13, K13, Ka13, Krt-1.13, Krt1-13, ck13, k13
(140), (37), (35), (4), (3), (3), (2), (2), (1), (1), (1)
(62), (62), (19), (3)
Clonality (Clone)
Monoclonal ()
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(112), (51), (48), (38), (30), (23), (11), (9), (8), (4), (3), (1), (1), (1)
Pubmed 6 references available
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Quantity 1 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Cytokeratin purified from Human esophagus
Clone 1C7
Isotype IgG2a
Specificity This Monoclonal Antibody Clone 1C7 does stain non-cornifying squamous epithelium.In Immunoblotting experiments the antibody recognizes only Keratin 13 (54 kDa) and does not show any cross reactivity with other keratins. The antibody is a useful Marker for histopathology. Frozen sections give excellent results in immunoperoxidase and immunofluorescence tests.Cross reactivity:Vimentin : not detectableDesmin : not detectableGFAP : not detectableNeurofilament : not detectable.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Supernatant
Alternative Name Cytokeratin 13 (KRT13 Antibody Abstract)
Background Cytokeratin 13 is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus.Synonyms: CK-13, CK13, K13, KRT-13, KRT13, Keratin type I cytoskeletal 13, Keratin-13
Gene ID 3860
NCBI Accession NP_002265
UniProt P13646
Research Area Signaling, Cytoskeleton, Extracellular Matrix
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer 10 mM Sodium Azide, FCS
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or at -20 °C for longer.
Background publications Blumberg: "Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture." in: Cancer research, Vol. 48, Issue 1, pp. 1-8, 1988 (PubMed).

Kasper, Stosiek, van Muijen et al.: "Cell type heterogeneity of intermediate filament expression in epithelia of the human pituitary gland." in: Histochemistry, Vol. 93, Issue 1, pp. 93-103, 1990 (PubMed).

Kopan, Traska, Fuchs: "Retinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization." in: The Journal of cell biology, Vol. 105, Issue 1, pp. 427-40, 1987 (PubMed).

van Muijen, Ruiter, Franke et al.: "Cell type heterogeneity of cytokeratin expression in complex epithelia and carcinomas as demonstrated by monoclonal antibodies specific for cytokeratins nos. 4 and 13." in: Experimental cell research, Vol. 162, Issue 1, pp. 97-113, 1986 (PubMed).

van Niekerk, Boerman, Ramaekers et al.: "Marker profile of different phases in the transition of normal human ovarian epithelium to ovarian carcinomas." in: The American journal of pathology, Vol. 138, Issue 2, pp. 455-63, 1991 (PubMed).

Smedts, Ramaekers, Troyanovsky et al.: "Keratin expression in cervical cancer." in: The American journal of pathology, Vol. 141, Issue 2, pp. 497-511, 1992 (PubMed).

Catalog No. ABIN1106902
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