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Keratin 15 (KRT15) antibody

Details for Product No. ABIN1106913, Supplier: Log in to see
Antigen
  • xlk2
  • CK15
  • K15
  • K1CO
  • AI528832
  • Krt1-15
  • Ka15
  • wu:fa91c06
  • wu:fa95d04
  • zgc:55334
Reactivity
Human
86
34
32
8
1
1
Host
Mouse
51
30
8
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
2
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
64
39
34
23
20
10
8
7
4
2
1
1
Supplier
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Clone 6-00E-007
Isotype IgG2a
Specificity This antibody reacts to KRT15.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name Cytokeratin 15 (KRT15 Antibody Abstract)
Background The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 15 is a type I keratin without a defined type II partner. Keratin 15 is expressed primarily in the basal keratinocytes of stratified tissues, including the fetal epidermis and fetal nail. Expression of keratin 15 is downregulated in some hyperproliferating situations, such as psoriasis and hypertrophic scars. Because keratinocytes in psoriasis and hypertrophic scars are activated, it is suggested that keratin 15 expression is not compatible with keratinocyte activation and the keratin 15 gene is downregulated to maintain the activated phenotype.Synonyms: CK-15, Cytokeratin-15, K15, KRT15, KRTB, Keratin, Keratin 15, Keratin-15, Type I Cytoskeletal 15
Molecular Weight 49 kDa
Gene ID 3866
Research Area Signaling, Cytoskeleton, Cytokeratins, Extracellular Matrix
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Immunohistochemistry (IHC) image for anti-Keratin 15 (KRT15) antibody (ABIN1106913) anti-Keratin 15 (KRT15) antibody
Flow Cytometry (FACS) image for anti-Keratin 15 (KRT15) antibody (ABIN1106913) anti-Keratin 15 (KRT15) antibody (Image 2)
Immunofluorescence (IF) image for anti-Keratin 15 (KRT15) antibody (ABIN1106913) anti-Keratin 15 (KRT15) antibody (Image 3)
Western Blotting (WB) image for anti-Keratin 15 (KRT15) antibody (ABIN1106913) anti-Keratin 15 (KRT15) antibody (Image 4)
Background publications Radoja, Stojadinovic, Waseem et al.: "Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription." in: Molecular and cellular biology, Vol. 24, Issue 8, pp. 3168-79, 2004 (PubMed).

Waseem, Dogan, Tidman et al.: "Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes." in: The Journal of investigative dermatology, Vol. 112, Issue 3, pp. 362-9, 1999 (PubMed).