Keratin 2 (KRT2) (N-Term) antibody

Details for Product No. ABIN1106928
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Antigen
Synonyms KRT2, krt2a, CK-2e, K2e, KRT2A, KRT2E, KRTE, BB005427, Krt2-17, Krt2-2, Krt2e, Kb2, K2E
Epitope
N-Term
(8), (7), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
(24), (7), (4), (3), (2), (1), (1)
Host
Mouse
(14), (13), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(28), (17), (14), (12), (7), (7), (6), (2), (1), (1)
Pubmed 2 references available
Quantity 1 mL
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Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN1106928
313.50 $
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Immunogen Synthetic peptide (N-terminal amino acids Nos. 2-23) of Human Cytokeratin 2e (MW 65,852).
Clone Ks2-342-7-1
Isotype IgG1
Specificity Clone Ks 2.342.7.1 represents an excellent marker to study terminal epidermal differentiation. It is reactive with epidermal cells in uppermost suprabasal layers including scalp, foot and sole. It recognizes individual cells within epidermis of tongue and mamille (co-localization with keratin K10). It is also reactive on hyperkeratosis of diverse viral and genetic origin. The antibody does not react with palate Cytokeratin 2P.
Cross-Reactivity (Details) Species reactivity (tested):Human, Bovine*, Mouse** and Rat**.
Purification Supernatant
Alternative Name Cytokeratin 2e
Background Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 - 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.Synonyms: CK2e, Cytokeratin-2e, K2e, KRT2, KRT2A, KRT2E, Keratin, Keratin-2, type II cytoskeletal 2 epidermal
Gene ID 3849
NCBI Accession NP_000414
UniProt P35908
Research Area Extracellular Matrix
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications Collin, Moll, Kubicka et al.: "Characterization of human cytokeratin 2, an epidermal cytoskeletal protein synthesized late during differentiation." in: Experimental cell research, Vol. 202, Issue 1, pp. 132-41, 1992 (PubMed).

Swensson, Langbein, McMillan et al.: "Specialized keratin expression pattern in human ridged skin as an adaptation to high physical stress." in: The British journal of dermatology, Vol. 139, Issue 5, pp. 767-75, 1999 (PubMed).

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