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Desmoglein 3 antibody
DSG3
Reactivity: Human
WB, IF, IP, IHC (p), IHC (fro)
Host: Mouse
Monoclonal
5G11
unconjugated
Product Details anti-Desmoglein 3 Antibody
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Target
See all Desmoglein 3 (DSG3) Antibodies
Desmoglein 3 (DSG3)
Reactivity
All reactivities for Desmoglein 3 antibodies
Human
Host
All hosts for Desmoglein 3 antibodies
Mouse
Clonality
All clonalities for Desmoglein 3 antibodies
Monoclonal
Conjugate
All conjugates for Desmoglein 3 antibodies
This Desmoglein 3 antibody is un-conjugated
Application
All applications for Desmoglein 3 antibodies
Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
Specificity
The monoclonal antibody 5G11 reacts with the 140 kDa desmoglein 3 protein. Furthermore it is not cross reactive with desmoglein 1 or desmoglein 2.
Cross-Reactivity (Details)
Species reactivity (tested):Human
Purification
Protein G
Clone
5G11
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.1 mg/mL
Buffer
PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
Storage
4 °C/-20 °C
Storage Comment
Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for Desmoglein 3
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Target
Desmoglein 3 (DSG3)
Alternative Name
Desmoglein-3 (DSG3 Products )
Synonyms
DSG3 antibody, CDHF6 antibody, PVA antibody, bal antibody, balding antibody, desmoglein 3 antibody, DSG3 antibody, Dsg3 antibody
Background
Desmoglein 3 is a member of the desmosomal cadherin family that comprise the desmogleins and desmocollins. Desmosomes are cell-cell junctions in most epithelial cells and serve to link the intermediate filament cytoskeletons of adjacent cells. Within the desmosome the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 3 is synthesized in both the basal and the lower suprabasal compartments.Synonyms: 130 kDa pemphigus vulgaris antigen, CDHF6, Cadherin family member 6, DSG3, PVA
Gene ID
1830
NCBI Accession
NP_001935
UniProt
P32926
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