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Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody

Details for Product No. ABIN1107001, Supplier: Login to see
Antigen
  • PRKDC
  • AI326420
  • AU019811
  • DNA-PKcs
  • DNAPDcs
  • DNAPK
  • DNPK1
  • DOXNPH
  • HYRC1
  • XRCC7
  • dxnph
  • p460
  • scid
  • slip
  • HYRC
  • p350
  • dna-pkcs
  • dnapk
  • dnpk1
  • hyrc
  • hyrc1
  • prkdc-A
  • xrcc7
  • DNA-PKCS
Alternatives
anti-Human Protein Kinase, DNA-Activated, Catalytic Polypeptide antibody for Electrophoretic Mobility-Shift Assay
Reactivity
Human
372
125
40
5
4
4
3
3
2
1
1
1
Host
Mouse
304
73
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
18
17
16
9
8
8
8
7
7
7
7
7
7
7
7
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
170
130
99
80
73
73
50
21
16
8
7
6
3
2
2
1
1
1
Supplier
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Clone 3H6
Isotype IgG1
Specificity Recognizes DNA-PKcs / PRKDC / XRCC7
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name DNA-PKcs / PRKDC / XRCC7 (PRKDC Antibody Abstract)
Background The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity, PRKDC must be bound to DNA to express its catalytic properties.Synonyms: DNA-dependent protein kinase catalytic subunit, DNPK1, HYRC, HYRC1, p460
Molecular Weight 46.9 kDa
Gene ID 5591
Pathways DNA Damage Repair
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
ELISA image for anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (ABIN1107001) anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody
Western Blotting (WB) image for anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (ABIN1107001) anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (ABIN1107001) anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (Image 3)
Immunohistochemistry (IHC) image for anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (ABIN1107001) anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (Image 4)
Immunofluorescence (IF) image for anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (ABIN1107001) anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (Image 5)
Background publications Durkin, Guo, Fryrear et al.: "HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase." in: The Journal of biological chemistry, Vol. 283, Issue 52, pp. 36311-20, 2008 (PubMed).

Isono, Ohshima, Saeki et al.: "Human T-cell leukemia virus type 1 HBZ protein bypasses the targeting function of ubiquitination." in: The Journal of biological chemistry, Vol. 283, Issue 49, pp. 34273-82, 2008 (PubMed).

Huston, Lynch, Mohamed et al.: "EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 35, pp. 12791-6, 2008 (PubMed).