Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody

Details for Product No. ABIN1107001
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Antigen
Synonyms PRKDC, AI326420, AU019811, DNA-PKcs, DNAPDcs, DNAPK, DNPK1, DOXNPH, HYRC1, XRCC7, dxnph, p460, scid, slip, HYRC, p350, dna-pkcs, dnapk, dnpk1, hyrc, hyrc1, prkdc-A, xrcc7, DNA-PKCS
Reactivity
Human
(272), (107), (42), (29), (28), (13), (4), (3), (1), (1)
Host
Mouse
(216), (59), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(14), (11), (11), (7), (7), (7), (7), (7), (7), (7), (7), (4), (4), (4)
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(132), (79), (70), (69), (63), (46), (46), (18), (13), (9), (8), (7), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1107001
423.50 $
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Clone 3H6
Isotype IgG1
Specificity Recognizes DNA-PKcs / PRKDC / XRCC7
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name DNA-PKcs / PRKDC / XRCC7
Background The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity, PRKDC must be bound to DNA to express its catalytic properties.Synonyms: DNA-dependent protein kinase catalytic subunit, DNPK1, HYRC, HYRC1, p460
Molecular Weight 46.9 kDa
Gene ID 5591
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (2) anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (Image 2)
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (3) anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (Image 3)
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (4) anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (Image 4)
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (5) anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (Image 5)
Background publications Huston, Lynch, Mohamed et al.: "EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 35, pp. 12791-6, 2008 (PubMed).

Isono, Ohshima, Saeki et al.: "Human T-cell leukemia virus type 1 HBZ protein bypasses the targeting function of ubiquitination." in: The Journal of biological chemistry, Vol. 283, Issue 49, pp. 34273-82, 2008 (PubMed).

Durkin, Guo, Fryrear et al.: "HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase." in: The Journal of biological chemistry, Vol. 283, Issue 52, pp. 36311-20, 2008 (PubMed).

Validation Images
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