PRKDC antibody (Protein Kinase, DNA-Activated, Catalytic Polypeptide)

Details for Product anti-PRKDC Antibody No. ABIN1107001, Supplier: Log in to see
Antigen
  • PRKDC
  • AI326420
  • AU019811
  • DNA-PKcs
  • DNAPDcs
  • DNAPK
  • DNPK1
  • DOXNPH
  • HYRC1
  • XRCC7
  • dxnph
  • p460
  • scid
  • slip
  • HYRC
  • p350
  • dna-pkcs
  • dnapk
  • dnpk1
  • hyrc
  • hyrc1
  • prkdc-A
  • xrcc7
  • DNA-PKCS
  • protein kinase, DNA-activated, catalytic polypeptide
  • protein kinase, DNA activated, catalytic polypeptide
  • PRKDC
  • Prkdc
  • prkdc
Alternatives
anti-Hamster PRKDC antibody for Electrophoretic Mobility-Shift Assay
Reactivity
Human
412
157
57
13
9
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6
3
3
2
2
2
2
1
1
1
Host
Mouse
318
98
3
1
Clonality (Clone)
Monoclonal ()
Conjugate
This PRKDC antibody is un-conjugated
21
19
17
9
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8
8
8
7
7
7
7
7
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7
5
5
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
204
141
110
107
89
88
60
39
15
11
7
6
5
3
2
2
2
1
Options
Supplier
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Supplier Product No.
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Clone 3H6
Isotype IgG1
Specificity Recognizes DNA-PKcs / PRKDC / XRCC7
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name DNA-PKcs / PRKDC / XRCC7 (PRKDC Antibody Abstract)
Background The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity, PRKDC must be bound to DNA to express its catalytic properties.Synonyms: DNA-dependent protein kinase catalytic subunit, DNPK1, HYRC, HYRC1, p460
Molecular Weight 46.9 kDa
Gene ID 5591
Pathways DNA Damage Repair, Production of Molecular Mediator of Immune Response
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
ELISA image for anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (ABIN1107001) anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody
Western Blotting (WB) image for anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (ABIN1107001) anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (ABIN1107001) anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (Image 3)
Immunohistochemistry (IHC) image for anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (ABIN1107001) anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (Image 4)
Immunofluorescence (IF) image for anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (ABIN1107001) anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (Image 5)
Background publications Isono, Ohshima, Saeki, Matsumoto, Hijikata, Tanaka, Shimotohno: "Human T-cell leukemia virus type 1 HBZ protein bypasses the targeting function of ubiquitination." in: The Journal of biological chemistry, Vol. 283, Issue 49, pp. 34273-82, 2008 (PubMed).

Durkin, Guo, Fryrear, Mihaylova, Gupta, Belgnaoui, Haoudi, Kupfer, Semmes: "HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase." in: The Journal of biological chemistry, Vol. 283, Issue 52, pp. 36311-20, 2008 (PubMed).

Huston, Lynch, Mohamed, Collins, Hill, MacLeod, Krause, Baillie, Houslay: "EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 35, pp. 12791-6, 2008 (PubMed).

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