Deoxyuridine Triphosphatase (DUT) (Middle Region) antibody

Catalog No. ABIN1107021

Product Details

Target: Deoxyuridine Triphosphatase (DUT)

Binding Specificity: Middle Region

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Specificity: This antibody detects DUT in the middle. No cross reactivity with other roteins.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Immunogen affinity purified

Immunogen: Synthetic peptide corresponding to a sequence mapping at the middle region of human dUTPase .Remarks: Sequence is identical to the related rat and ouse sequence.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg himerosal, 0.05 mg NaN3

Preservative: Sodium azide, Thimerosal (Merthiolate)

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details

Target: Deoxyuridine Triphosphatase (DUT)

Alternative Name: DUT (DUT Products)

Synonyms: BcDNA:LD08534 antibody, CG4584 antibody, Dmel\\CG4584 antibody, LD08534 antibody, UTPase antibody, anon-SAGE:Wang-077 antibody, dUTPase antibody, Tb07.27E10.390 antibody, dutpase antibody, 5031412I06Rik antibody, 5133400F09Rik antibody, D2Bwg0749e antibody, Dutp antibody, PIP4 antibody, deoxyuridine triphosphatase antibody, Deoxyuridine triphosphatase antibody, dUTPase; ORF54; similar to EBV BLLF3, CMV UL72, HSV UL50 antibody, involved in nucleotide metabolism antibody, tegument protein antibody, dUTPase antibody, deoxyuridine triphosphatase L homeolog antibody, DUT antibody, dUTPase antibody, P18 antibody, AlHV1gp51 antibody, UL50 antibody, HVT058 antibody, ORF9 antibody, ORF8 antibody, U45 antibody, GAMMAHV.ORF54 antibody, Tc00.1047053509151.130 antibody, Tc00.1047053508175.160 antibody, Tb927.7.5160 antibody, dut.L antibody, Dut antibody

Target Type: Viral Protein

Background: Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) is responsible for maintaining low ntracellular levels of dUTP, thus preventing the incorporation of dUTP into DNA. DUTPase ctivity/expression can be down-regulated using siRNA specifically targeted to dUTPase mRNA and UTPase plays a role in DNA nucleotide metabolism. This protein, present predominantly in the ytoplasm, contains 252 amino acids with a Mr of 26,704. It exhibits 35 % identity with the E. coli UTPase and 53 % identity with the Saccharomyces cerevisiae enzyme. The nuclear and mitochondrial orms of dUTPase are encoded by the same gene with isoform-specific transcripts arising through the se of alternative 5-prime exons. Human dUTPase exhibits 92 % identity with rat. Moreover, this nzyme has profound effects on the efficacy of agents that target thymidylate biosynthesis.Synonyms: Deoxyuridine 5'-triphosphate nucleotidohydrolase mitochondrial, dUTP pyrophosphatase, dUTPase

Gene ID: 1854

NCBI Accession: NP_001020419

UniProt: P33316