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EPH Receptor B6 antibody (EPHB6)

Details for Product anti-EPHB6 Antibody No. ABIN1107117, Supplier: Login to see
Antigen
  • CEK9
  • EPHB5
  • Cekl
  • Mep
  • HEP
Alternatives
anti-Human EPH Receptor B6 antibody for Enzyme Immunoassay
Reactivity
Human
130
39
30
2
1
1
Host
Mouse
101
27
7
2
Clonality (Clone)
Monoclonal ()
Conjugate
This EPH Receptor B6 antibody is un-conjugated
7
7
7
7
6
6
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
104
83
61
25
16
11
11
4
2
1
1
1
Supplier
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Clone 2A6B9
Isotype IgG1
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name EPHB6 (EPHB6 Antibody Abstract)
Background EhpB6: EPH receptor B6. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.Synonyms: EPH-6, Ephrin type-B receptor 6, HEP, Tyrosine-protein kinase-defective receptor EPH-6
Gene ID 2051
Pathways RTK Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Western Blotting (WB) image for anti-EPH Receptor B6 antibody (EPHB6) (ABIN1107117) anti-EPH Receptor B6 (EPHB6) antibody
Immunohistochemistry (IHC) image for anti-EPH Receptor B6 antibody (EPHB6) (ABIN1107117) anti-EPH Receptor B6 (EPHB6) antibody (Image 2)
Background publications Fox, Kandpal: "Transcriptional silencing of EphB6 receptor tyrosine kinase in invasive breast carcinoma cells and detection of methylated promoter by methylation specific PCR." in: Biochemical and biophysical research communications, Vol. 340, Issue 1, pp. 268-76, 2005 (PubMed).

Freywald, Sharfe, Rashotte et al.: "The EphB6 receptor inhibits JNK activation in T lymphocytes and modulates T cell receptor-mediated responses." in: The Journal of biological chemistry, Vol. 278, Issue 12, pp. 10150-6, 2003 (PubMed).

Luo, Yu, Wu et al.: "EphB6 crosslinking results in costimulation of T cells." in: The Journal of clinical investigation, Vol. 110, Issue 8, pp. 1141-50, 2002 (PubMed).

Freywald, Sharfe, Roifman: "The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1." in: The Journal of biological chemistry, Vol. 277, Issue 6, pp. 3823-8, 2002 (PubMed).