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Estrogen Receptor alpha antibody (Estrogen Receptor 1)

Details for Product anti-ESR1 Antibody No. ABIN1107139, Supplier: Login to see
Antigen
  • ACTGP1
  • ACT1GP1
  • HY-psi-gamma-AC6
  • ER[b]2
  • ER[b]a
  • zfER[b]2
  • zfER-beta2
  • XER
  • era
  • esr
  • esra
  • nr3a1
  • ERbeta
  • xesr-1
  • ERalpha
  • xlERalpha1
  • xlERalpha2
  • LOC398733
  • LOC398734
  • 2610524P08Rik
  • 9130407C09Rik
  • AU019798
  • Era
  • M-ERA
  • MERA-S
  • MERA-W
  • ERA
  • ERAL1A
  • H-ERA
  • HERA-A
  • HERA-B
  • er
  • esr1
  • ER
  • ESR
  • ESRA
  • ESTRR
  • NR3A1
  • ER-alpha
  • Esr
  • RNESTROR
  • ERALPHA
  • ER[a]
  • eralpha
  • zfER[a]
  • ESR1
  • AA420328
  • AU041214
  • ERa
  • Estr
  • Estra
  • Nr3a1
Alternatives
anti-Human Estrogen Receptor alpha antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human
825
279
167
27
11
11
11
7
6
4
3
2
1
1
Host
Mouse
632
232
8
3
3
Clonality (Clone)
Monoclonal ()
Conjugate
This Estrogen Receptor alpha antibody is un-conjugated
31
31
28
15
14
14
10
8
8
8
8
8
8
8
8
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
629
272
272
171
122
92
71
39
27
15
12
8
8
6
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
Supplier
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Clone 5D4B1
Isotype IgG2b
Specificity Recognizes ER (Estrogen Receptor 1).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name Estrogen Receptor alpha (ESR1 Antibody Abstract)
Background ER (Estrogen Receptor 1) a member of the steroid receptor superfamily, contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ER regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery. Phosphorylation provides an important mechanism to regulate ER activity. ER is phosphorylated on multiple sites. Serines 104, 106, 118 and 167 are located in the amino-terminal transcription activation function domain AF-1, and phosphorylation of these serines plays an important role in regulating ER activity. Ser118 may be the substrate of the transcription regulatory kinase cdK7. Ser167 may be phosphorylated by p90RSK and Akt. Phosphorylation of Ser167 may confer tamoxifen resistance in breast cancer patients.Synonyms: ER alpha, ESR, ESR1, Estradiol receptor, NR3A1, Nuclear receptor subfamily 3 group A member 1
Gene ID 2099
Research Area Cancer, Endocrine system, Transcription Factors, Hormones, Receptors
Pathways Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Western Blotting (WB) image for anti-Estrogen Receptor alpha antibody (Estrogen Receptor 1) (ABIN1107139) anti-Estrogen Receptor 1 (ESR1) antibody
Western Blotting (WB) image for anti-Estrogen Receptor alpha antibody (Estrogen Receptor 1) (ABIN1107139) anti-Estrogen Receptor 1 (ESR1) antibody (Image 2)
Background publications Campbell, Bhat-Nakshatri, Patel et al.: "Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance." in: The Journal of biological chemistry, Vol. 276, Issue 13, pp. 9817-24, 2001 (PubMed).

Chen, Riedl, Washbrook et al.: "Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7." in: Molecular cell, Vol. 6, Issue 1, pp. 127-37, 2000 (PubMed).