Estrogen Receptor 1 (ESR1) antibody

Details for Product No. ABIN1107139
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Antigen
Synonyms
ACTGP1, ACT1GP1, HY-psi-gamma-AC6, ER[b]2, ER[b]a, zfER[b]2, zfER-beta2, XER, era, esr, esra, nr3a1, ERbeta, xesr-1, ERalpha, xlERalpha1, xlERalpha2, LOC398733, LOC398734, 2610524P08Rik, 9130407C09Rik ... show more
ACTGP1, ACT1GP1, HY-psi-gamma-AC6, ER[b]2, ER[b]a, zfER[b]2, zfER-beta2, XER, era, esr, esra, nr3a1, ERbeta, xesr-1, ERalpha, xlERalpha1, xlERalpha2, LOC398733, LOC398734, 2610524P08Rik, 9130407C09Rik, AU019798, Era, M-ERA, MERA-S, MERA-W, ERA, ERAL1A, H-ERA, HERA-A, HERA-B, er, esr1, ER, ESR, ESRA, ESTRR, NR3A1, ER-alpha, Esr, RNESTROR, ERALPHA, ER[a], eralpha, zfER[a], ESR1, AA420328, AU041214, ERa, Estr, Estra, Nr3a1 show less
Reactivity
Human
(653), (258), (151), (53), (39), (27), (14), (11), (3), (2), (1), (1), (1), (1), (1)
Host
Mouse
(527), (158), (8), (3), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(23), (19), (18), (10), (10), (10), (10), (10), (10), (10), (10), (7), (7), (7)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(502), (206), (204), (197), (105), (100), (67), (50), (33), (30), (18), (10), (8), (4), (3), (2), (1), (1), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1107139
335.50 $
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Clone 5D4B1
Isotype IgG2b
Specificity Recognizes ER (Estrogen Receptor 1).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name Estrogen Receptor alpha
Background ER (Estrogen Receptor 1) a member of the steroid receptor superfamily, contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ER regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery. Phosphorylation provides an important mechanism to regulate ER activity. ER is phosphorylated on multiple sites. Serines 104, 106, 118 and 167 are located in the amino-terminal transcription activation function domain AF-1, and phosphorylation of these serines plays an important role in regulating ER activity. Ser118 may be the substrate of the transcription regulatory kinase cdK7. Ser167 may be phosphorylated by p90RSK and Akt. Phosphorylation of Ser167 may confer tamoxifen resistance in breast cancer patients.Synonyms: ER alpha, ESR, ESR1, Estradiol receptor, NR3A1, Nuclear receptor subfamily 3 group A member 1
Gene ID 2099
Research Area Cancer, Endocrine system, Transcription Factors, Hormones, Receptors
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
anti-Estrogen Receptor 1 (ESR1) antibody anti-Estrogen Receptor 1 (ESR1) antibody
anti-Estrogen Receptor 1 (ESR1) antibody (2) anti-Estrogen Receptor 1 (ESR1) antibody (Image 2)
Background publications Chen, Riedl, Washbrook et al.: "Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7." in: Molecular cell, Vol. 6, Issue 1, pp. 127-37, 2000 (PubMed).

Campbell, Bhat-Nakshatri, Patel et al.: "Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance." in: The Journal of biological chemistry, Vol. 276, Issue 13, pp. 9817-24, 2001 (PubMed).

Validation Images
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