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Fatty Acid Binding Protein 2, Intestinal (FABP2) antibody

Details for Product No. ABIN1107163, Supplier: Log in to see
Antigen
  • I-FABP
  • ifabp
  • zgc:92264
  • IFABP
  • fabpi
  • i-fabp
  • fabp2-A
  • FABP2
  • FABPI
  • FABP
  • Fabpi
  • fabp2
  • fabp2a
Reactivity
Human
127
36
31
6
6
3
3
2
1
Host
Mouse
79
43
25
4
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
10
9
4
3
3
3
2
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
105
102
58
18
15
9
8
8
5
5
4
3
2
Supplier
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Clone 9A9B7B3
Isotype IgG1
Specificity This antibody reacts to FABP2.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name FABP2 (FABP2 Antibody Abstract)
Background The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. Genetic variation in FABP2 may thus contribute to interindividual variation in the response of plasma lipoproteins to different dietary fibres, but the mechanism does not appear to be related to increases in fecal bile acid secretion.Synonyms: FABP-2, FABPI, Fatty acid-binding protein, I-FABP, intestinal
Molecular Weight 15 kDa
Gene ID 2169
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Immunohistochemistry (IHC) image for anti-Fatty Acid Binding Protein 2, Intestinal (FABP2) antibody (ABIN1107163) anti-Fatty Acid Binding Protein 2, Intestinal (FABP2) antibody
Flow Cytometry (FACS) image for anti-Fatty Acid Binding Protein 2, Intestinal (FABP2) antibody (ABIN1107163) anti-Fatty Acid Binding Protein 2, Intestinal (FABP2) antibody (Image 2)
Immunofluorescence (IF) image for anti-Fatty Acid Binding Protein 2, Intestinal (FABP2) antibody (ABIN1107163) anti-Fatty Acid Binding Protein 2, Intestinal (FABP2) antibody (Image 3)
Western Blotting (WB) image for anti-Fatty Acid Binding Protein 2, Intestinal (FABP2) antibody (ABIN1107163) anti-Fatty Acid Binding Protein 2, Intestinal (FABP2) antibody (Image 4)
Background publications Fisher, Li, Burwinkel et al.: "Preliminary evidence of FABP2 A54T polymorphism associated with reduced risk of type 2 diabetes and obesity in women from a German cohort." in: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme, Vol. 38, Issue 5, pp. 341-5, 2006 (PubMed).

Kim, Yun, Byun et al.: "Codon 54 polymorphism of the fatty acid binding protein 2 gene is associated with increased fat oxidation and hyperinsulinemia, but not with intestinal fatty acid absorption in Korean men." in: Metabolism: clinical and experimental, Vol. 50, Issue 4, pp. 473-6, 2001 (PubMed).

Georgopoulos, Aras, Tsai: "Codon-54 polymorphism of the fatty acid-binding protein 2 gene is associated with elevation of fasting and postprandial triglyceride in type 2 diabetes." in: The Journal of clinical endocrinology and metabolism, Vol. 85, Issue 9, pp. 3155-60, 2000 (PubMed).

Yamada, Yuan, Ishiyama et al.: "Association between Ala54Thr substitution of the fatty acid-binding protein 2 gene with insulin resistance and intra-abdominal fat thickness in Japanese men." in: Diabetologia, Vol. 40, Issue 6, pp. 706-10, 1997 (PubMed).