GNRHR antibody (Extracellular Domain, N-Term)

Catalog No. ABIN1107411

Product Details anti-GNRHR Antibody

Target: GNRHR (Gonadotropin-Releasing Hormone Receptor (GNRHR))

Binding Specificity: AA 1-29, Extracellular Domain, N-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GNRHR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Sequence: MANSASPEQN QHCSAINNSI PLMQGNLPY

Specificity: This Monoclonal antibody F1G4 reacts with GnRH receptors in the anterior pituitary. F1G4 showed specificity for the synthetic peptide in ELISA and Dot blot.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Purified

Immunogen: Mice were immunized with a BSA-conjugated peptide corresponding to amino acids 1-29 of Human GnRH receptor extracellular domain. Splenocytes were fused with SP2/0 mouse myeloma cells. Stability was established by subcloning four times.

Clone: F1G4

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GNRHR

Target: GNRHR (Gonadotropin-Releasing Hormone Receptor (GNRHR))

Alternative Name: GnRH Receptor / GNRHR (GNRHR Products)

Synonyms: GNRHR1 antibody, GRHR antibody, HH7 antibody, LHRHR antibody, LRHR antibody, GNRHR antibody, GH1 antibody, Lhrhr antibody, GNRHR1/III antibody, GNRHR2 antibody, xgnrhr antibody, gnrhr3/ii antibody, gnrh-r antibody, gonadotropin releasing hormone receptor antibody, gonadotropin-releasing hormone receptor antibody, GNRHR antibody, Gnrhr antibody, gnrhr antibody, gnrh-r antibody

Background: Gonadotropin Releasing Hormone (GnRH) is down-regulated by hCG and believed to be an autocrine factor that regulates the ovary. The Gonadotropin Releasing Hormone Receptor (GnRHR) is synthesized in the pituitary gland. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinising hormone (LH) as well as follicle-stimulating hormone (FSH). The receptor contains of seven hydrophobic transmembrane domains connected by hydrophillic extracellular, and intracellular loops characteristic of G-protein coupled receptors.Gonadotropin Releasing Hormone (GnRH) is down-regulated by hCG and believed to be an autocrine factor that regulates the ovary. The Gonadotropin Releasing Hormone Receptor (GnRHR) is synthesized in the pituitary gland. Synonyms: GRHR, GnRH-R, Gonadotropin-releasing hormone receptor

Gene ID: 2798

NCBI Accession: NP_000397

UniProt: P30968