HMGB1 antibody
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- Target See all HMGB1 Antibodies
- HMGB1 (High Mobility Group Box 1 (HMGB1))
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Reactivity
- Human, Mouse, Rat, Pig
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This HMGB1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Specificity
- This antibody reacts with human, mouse, rat and porcine HMGB1.
- Purification
- Protein A agarose
- Immunogen
- Porcine HMGB1
- Clone
- KS1
- Isotype
- IgG2a
- Top Product
- Discover our top product HMGB1 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.
- Preservative
- Without preservative
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- -20 °C
- Storage Comment
- Store (in aliquots) at -20 °C.
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- Target
- HMGB1 (High Mobility Group Box 1 (HMGB1))
- Alternative Name
- HMGB1 (HMGB1 Products)
- Synonyms
- HMG1 antibody, HMG3 antibody, SBP-1 antibody, DEF antibody, HMG-1 antibody, Hmg1 antibody, amphoterin antibody, p30 antibody, hmgb1 antibody, ik:tdsubc_1a5 antibody, wu:fb23c02 antibody, xx:tdsubc_1a5 antibody, zgc:56110 antibody, zgc:77104 antibody, hmg-1 antibody, hmg3 antibody, sbp-1 antibody, hmg1 antibody, HMGB1 antibody, Ac2-008 antibody, high mobility group box 1 antibody, high-mobility group box 1 antibody, high mobility group box 1a antibody, high mobility group box 1 L homeolog antibody, high mobility group protein B1 antibody, HMGB1 antibody, Hmgb1 antibody, hmgb1 antibody, hmgb1a antibody, hmgb1.L antibody, LOC100359149 antibody
- Background
- High mobility group box 1 (HMGB1), named for its rapid migration properties on electrophoretic gels, is a member of the nonhistone chromatin-associated proteins. HMGB1 is translated as a 214 amino acid protein and is extensively modified posttranslationally by glycosylation, acylation, methylation, and phosphorylation. The primary structure is evolutionarily conserved, with 100 % amino acid sequence homology between rat and mouse and 99 % homology between rodent and human. Intracellular HMGB1 has previously been studied for its roles in binding DNA, stabilizing nucleosome formation, as a general transcription factor for nucleolar and mitochondrial RNA polymerases, and as a gene- and tissue-specific transcriptional regulator that can enhance transcription and/or replication. Extracellular HMGB1 has recently been implicated as a late mediator of delayed endotoxin lethality, because murine and human macrophages/monocytes release large amounts of a 29 kDa form of HMGB1 when stimulated by exposure to bacterial endotoxin.Synonyms: Amphoterin, HMG-1, HMG1, HMGB-1, High mobility group protein 1, High mobility group protein B1
- Molecular Weight
- 29 kDa
- Gene ID
- 3146
- NCBI Accession
- NP_002119
- UniProt
- P09429
- Pathways
- p53 Signaling, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome
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