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IDO1 antibody (N-Term)

IDO1 Reactivity: Mouse, Rat WB, IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1107631
  • Target See all IDO1 Antibodies
    IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
    Binding Specificity
    • 16
    • 10
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-19, AA 155-176, AA 359-376, N-Term
    Reactivity
    • 62
    • 30
    • 16
    • 7
    • 1
    • 1
    • 1
    Mouse, Rat
    Host
    • 56
    • 11
    • 1
    • 1
    Rabbit
    Clonality
    • 55
    • 15
    Polyclonal
    Conjugate
    • 47
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IDO1 antibody is un-conjugated
    Application
    • 62
    • 32
    • 23
    • 19
    • 15
    • 15
    • 14
    • 8
    • 6
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    The antibody recognizes Rat Indoleamine 2,3-dioxygenase 1 (IDO1 or INDO). Does not cross react with IDO2.
    Cross-Reactivity (Details)
    Species reactivity (tested):Rat, Mouse.
    Purification
    Protein A Chromatography
    Immunogen
    A mixture of three Rat IDO peptides: MPHSQISPAEGSRRILEEY (1-19), LFSFPGGDCDKGFFLVSLMVE (155-176), and VKPSKQKPMGGHKSEEPS (359-376) coupled to keyhole limpet hemocyanin.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product IDO1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.1 mg/mL
    Buffer
    PBS, 0.02 % Sodium Azide, 0.1 % BSA
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store undiluted at 2-8 °C.
  • Target
    IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
    Alternative Name
    IDO1 / INDO (IDO1 Products)
    Synonyms
    INDO antibody, ido antibody, indo antibody, IDO antibody, cd107b antibody, IDO1 antibody, IDO-1 antibody, Ido antibody, Indo antibody, indoleamine 2,3-dioxygenase 1 antibody, indoleamine 2,3-dioxygenase 1 L homeolog antibody, indoleamine 2,3-dioxygenase 1-like antibody, IDO1 antibody, ido1.L antibody, ido1 antibody, Ido1 antibody, LOC100050681 antibody
    Background
    IDO1 is an intracellular heme-containing enzyme of 45 kD that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules, like tryptophan, serotonin and melatonin. By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines. IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs). In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction. The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms. Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites. Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and neoplasia. By local depletion of tryptophan and increasing proapoptotic kynurenines, IDO1 greatly affects T-cell proliferation and survival, both in vitro and in vivo, and also affects B-cell and NK-cell function and survival. There is a central role for IDO1 expression in tolerance involving regulatory cells and DCs. IDO1 acts as an intermediate pathway in LPS-induced production of reactive oxygen species and NF-kappaB activation, two processes that lead to DC maturation. In addition to classic IDO (IDO1) indoleamine 2,3-dioxygenase-2, indoleamine 2,3-dioxygenase-like protein or proto-indoleamine 2,3 dioxygenase (IDO2, IDO-2, INDOL1 or proto-IDO) has been described.Synonyms: 3-dioxygenase, 3-dioxygenase 1, EC=1.13.11.52, IDO, IDO1, INDO, Indoleamine 2, Indoleamine-pyrrole 2
    Gene ID
    66029
    NCBI Accession
    NP_076463
    UniProt
    Q9ERD9
    Pathways
    Activated T Cell Proliferation
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