Inhibin, alpha (INHA) antibody

Details for Product No. ABIN1107756
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Antigen
Synonyms si:dkey-91f15.2, INHA, MGC108500, AW555078
Reactivity
Human, Mouse (Murine)
(109), (31), (20), (13), (7), (6), (4)
Host
Mouse
(91), (39), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(10), (8), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
(71), (57), (47), (32), (26), (24), (20), (14), (8), (5), (4), (4), (2), (1)
Pubmed 3 references available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN1107756
390.50 $
Plus shipping costs $45.00

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Clone 4-00E-002
Isotype IgG1
Specificity Recognizes Inhibin alpha / INHA
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse.
Purification Ascites
Alternative Name Inhibin alpha / INHA
Background Inhibins are peptide hormones produced by the granulosa cells in female follicles and by Sertoli cells in the male seminiferous tubules. They are selectively expressed by cells of sex cord stromal derivation, and inhibit the secretion of follitropin by the pituitary gland. Inhibins are also involved in regulating diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins, as inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibin has 2 subunits (alpha and beta) that are coded by separate genes. The alpha subunit determines whether inhibin or activin will be produced. The alpha subunit remains constant, such that the various types of inhibin are defined by the beta subunit (a,b,c,d). Inhibin A is a dimer of alpha and beta A. Inhibin B is a dimer of alpha and beta B. Proteolytic processing yields a number of inhibin alpha bioactive forms: the 20/23 kDa forms consist solely of the mature alpha chain, the 26/29 kDa forms consist of the most N terminal propeptide linked through a disulfide bond to the mature alpha chain, and the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono or diglycosylated, causing the mass difference.
Molecular Weight 40 kDa
Gene ID 3623
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
anti-Inhibin, alpha (INHA) antibody anti-Inhibin, alpha (INHA) antibody
anti-Inhibin, alpha (INHA) antibody (2) anti-Inhibin, alpha (INHA) antibody (Image 2)
Background publications Palmieri, Wilson, Iversen et al.: "Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 17, Issue 12, pp. 3567-72, 2008 (PubMed).

Makovitzky, Radtke, Shabani et al.: "Invasive hydatidiform mole: immunohistochemical labelling of inhibin/activin subunits, Ki67, p53 and glycodelin A in a rare case." in: Acta histochemica, Vol. 111, Issue 4, pp. 360-5, 2009 (PubMed).

Corre, Schuettler, Bione et al.: "A large-scale association study to assess the impact of known variants of the human INHA gene on premature ovarian failure." in: Human reproduction (Oxford, England), Vol. 24, Issue 8, pp. 2023-8, 2009 (PubMed).

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