IFNA antibody

Catalog No. ABIN1107768

Product Details anti-IFNA Antibody

Target: IFNA (Interferon alpha (IFNA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IFNA antibody is un-conjugated

Application: Neutralization (Neut)

No Cross-Reactivity: Mouse (Murine)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Endotoxin Level: < 10 ng/mg of antibody, as determined by the LAL assay

Immunogen: Human IFN-alpha (purified)

Clone: #14

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS without preservatives

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store (in aliquots) at -20 °C.

Target Details for IFNA

Target: IFNA (Interferon alpha (IFNA))

Alternative Name: Interferon alpha (IFN Alpha) (IFNA Products)

Synonyms: IFN-alphaO antibody, IFN-ALPHA-1 antibody, IFN1@ antibody, Ifa antibody, Ifa8 antibody, interferon alpha 16 antibody, interferon, alpha 1 antibody, interferon alpha antibody, interferon-alpha antibody, IFNA16 antibody, IFNA1 antibody, Ifna antibody, IFNA antibody

Background: The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. Interferon alpha is produced primarily by plasmacytoid dendritic cells and is a potent component of the anti viral innate immune response, it modulates adaptive immunity. The classification of mammalian cytokines with antiviral activity, is well documented as being either Type I Interferon (IFNI) or Type II Interferon (IFNII). This is not the case for avian IFNs however, even though IFN was first detected in the chicken. A growing number of functional studies indicate similarities between chicken IFN and mammalian IFNI, revealing the conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes. Further research has shown that chIFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and that recombinant chicken IFN acts as a potent antiviral agent.Synonyms: B Cell Interferon, IFN-alpha, IFNA, Interferon-alpha, Leukocyte Interferon, Type I Interferon

Pathways: JAK-STAT Signaling, TLR Signaling, Hepatitis C, Inflammasome